RAPGEF5 and RAP2A

Data Source:
HPRD (in vitro)

		RAPGEF5	RAP2A
Description		Rap guanine nucleotide exchange factor 5	RAP2A, member of RAS oncogene family
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body	Cytosol Plasma Membrane Midbody Recycling Endosome Recycling Endosome Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTP-dependent Protein Binding	Magnesium Ion Binding GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Small GTPase Mediated Signal Transduction Nervous System Development Regulation Of Catalytic Activity	Positive Regulation Of Protein Phosphorylation Microvillus Assembly Negative Regulation Of Cell Migration Actin Cytoskeleton Reorganization Positive Regulation Of Protein Autophosphorylation Rap Protein Signal Transduction Cellular Protein Localization Cellular Response To Drug Establishment Of Protein Localization Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of JNK Cascade Regulation Of Dendrite Morphogenesis Protein Localization To Plasma Membrane
Pathways
Drugs			Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate
Diseases
GWAS		Cutaneous malignant melanoma ( 32341527) Depression in smokers ( 30219690) Dialysis-related mortality ( 21546767) Diastolic blood pressure ( 30224653) Glaucoma ( 30104761) Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) Night sleep phenotypes ( 27126917) Spatial processing ( 31596458) Squamous cell lung carcinoma ( 28604730) Thyroid stimulating hormone levels ( 17903292) Urinary albumin excretion ( 32277301)	Gut microbiota (bacterial taxa) ( 27723756) Peripheral artery disease ( 26488411)
Interacting Genes		7 interacting genes: MRAS PLAC9 RAP1A RAP2A RAP2B TMEM253 VANGL1	32 interacting genes: ACVR1 AFDN ARHGAP29 BMPR1B EEF1A1 ENSA FKBP2 FNTB FTL GABARAPL2 GRIN1 GRIN2D MAP4K4 NEDD4 PLG RAF1 RALGDS RAPGEF3 RAPGEF4 RAPGEF5 RAPGEF6 RASIP1 RASSF5 RGL1 RGS14 RRP9 RUNDC3A SERPINA1 SMAD1 TGFBR1 TM7SF2 TNIK
Entrez ID		9771	5911
HPRD ID		15208	01547
Ensembl ID		ENSG00000136237	ENSG00000125249
Uniprot IDs		A8MQ07 Q5JPD2 Q92565	P10114
PDB IDs		1WGY	1KAO 2RAP 3RAP
Enriched GO Terms of Interacting Partners?
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