SYTL4 and STXBP1

Data Source:
BioGRID (two hybrid)
HPRD (in vitro, in vivo)

		SYTL4	STXBP1
Description		synaptotagmin like 4	syntaxin binding protein 1
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GO Annotations	Cellular Component	Endosome Plasma Membrane Extrinsic Component Of Membrane Transport Vesicle Membrane Platelet Alpha Granule Membrane Exocytic Vesicle	Nucleoplasm Cytoplasm Mitochondrion Cytosol Cytoskeleton Plasma Membrane Secretory Granule Axon Platelet Alpha Granule Protein-containing Complex Phagocytic Vesicle Perinuclear Region Of Cytoplasm Presynaptic Active Zone Membrane Extracellular Exosome Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding Phospholipid Binding Neurexin Family Protein Binding Metal Ion Binding	SNARE Binding RNA Binding Protein Binding Syntaxin-1 Binding Protein Kinase Binding Protein Domain Specific Binding Syntaxin Binding Identical Protein Binding Phospholipase Binding Protein N-terminus Binding
	Biological Process	Plasma Membrane Repair Platelet Degranulation Intracellular Protein Transport Exocytosis Lysosome Localization Positive Regulation Of Exocytosis Negative Regulation Of Insulin Secretion Positive Regulation Of Protein Secretion Multivesicular Body Sorting Pathway Regulation Of Plasma Membrane Repair	Platelet Degranulation Developmental Process Involved In Reproduction Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Neurotransmitter Secretion Neuromuscular Synaptic Transmission Axon Target Recognition Regulation Of Synaptic Vesicle Priming Glutamate Secretion Synaptic Vesicle Priming Synaptic Vesicle Maturation Vesicle-mediated Transport Negative Regulation Of Protein-containing Complex Assembly Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Negative Regulation Of Synaptic Transmission, GABAergic Response To Estradiol SNARE Complex Assembly Regulation Of SNARE Complex Assembly Positive Regulation Of Mast Cell Degranulation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Calcium Ion-dependent Exocytosis Protein Stabilization Long-term Synaptic Depression Platelet Aggregation Cellular Response To Interferon-gamma Protein Localization To Plasma Membrane Presynaptic Dense Core Vesicle Exocytosis Positive Regulation Of Vesicle Docking Positive Regulation Of Glutamate Secretion, Neurotransmission Regulation Of Acrosomal Vesicle Exocytosis
Pathways		Platelet degranulation	Regulation of insulin secretion Neurexins and neuroligins
Drugs		Insulin pork
Diseases			Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Lean body mass ( 28552196) Mean platelet volume ( 32888494) Platelet distribution width ( 32888494)	Body size at age 10 ( 32376654) Whole brain grey matter density ( 31530798)
Interacting Genes		27 interacting genes: CCDC85B CEP70 DVL3 FCHO1 FXR2 HMG20A INS KIFC3 LMO1 LZTS1 OSBPL3 PRKAR1B RAB27A RAB27B RAB3A RAB3D RAB8A ROPN1 SPANXN2 STX1A STXBP1 TBC1D1 TRIM37 TRIM41 ZBTB7B ZBTB9 ZRANB1	34 interacting genes: APBA1 APBA2 APP BRME1 CDK5 CDK5R1 CENPP DOC2A DOC2B HGS MAPK1 MAPT MEOX2 MTDH MTNR1A NEFH NEFM PLD1 PLD2 PRKCA PRKCB PRKCG SPICE1 SPTBN1 SQSTM1 STX19 STX1A STX1B STX2 STX3 STX5 SYTL4 TRIM38 USO1
Entrez ID		94121	6812
HPRD ID		06735	04235
Ensembl ID		ENSG00000102362	ENSG00000136854
Uniprot IDs		A0A024RCF8 A8K973 B2R7R4 Q71SF7 Q96C24	P61764
PDB IDs		2CSZ 3FDW 5X6T	6L03
Enriched GO Terms of Interacting Partners?
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