SYTL4 and HMG20A

Data Source:
BioGRID (two hybrid)

		SYTL4	HMG20A
Description		synaptotagmin like 4	high mobility group 20A
Image			No pdb structure
GO Annotations	Cellular Component	Endosome Plasma Membrane Extrinsic Component Of Membrane Transport Vesicle Membrane Platelet Alpha Granule Membrane Exocytic Vesicle	Nucleus
	Molecular Function	Protein Binding Phospholipid Binding Neurexin Family Protein Binding Metal Ion Binding	DNA Binding Protein Binding Identical Protein Binding
	Biological Process	Plasma Membrane Repair Platelet Degranulation Intracellular Protein Transport Exocytosis Lysosome Localization Positive Regulation Of Exocytosis Negative Regulation Of Insulin Secretion Positive Regulation Of Protein Secretion Multivesicular Body Sorting Pathway Regulation Of Plasma Membrane Repair	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Negative Regulation Of Protein Sumoylation Negative Regulation Of Neuron Differentiation
Pathways		Platelet degranulation
Drugs		Insulin pork
Diseases
GWAS		Lean body mass ( 28552196) Mean platelet volume ( 32888494) Platelet distribution width ( 32888494)	Hand grip strength ( 29691431) Hemoglobin A1c levels ( 29403010) Medication use (drugs used in diabetes) ( 31015401) Type 2 diabetes ( 21490949 22885922 24509480 30054458 22693455 21874001 30297969 32499647 30718926 28869590)
Interacting Genes		27 interacting genes: CCDC85B CEP70 DVL3 FCHO1 FXR2 HMG20A INS KIFC3 LMO1 LZTS1 OSBPL3 PRKAR1B RAB27A RAB27B RAB3A RAB3D RAB8A ROPN1 SPANXN2 STX1A STXBP1 TBC1D1 TRIM37 TRIM41 ZBTB7B ZBTB9 ZRANB1	58 interacting genes: ADD1 AGR2 BACH2 BRAP C9orf72 CCDC136 CCNK CEP95 CFAP53 DCTN4 DDIT4L DGCR6L DTNA DTNB FBXO7 FMNL1 FOXD4L1 GADD45GIP1 GPSM1 GTF2A1L HMG20B HPCAL1 KIFC3 KPNA2 KRT1 LMO1 LNX1 LURAP1 MAGOHB NTAQ1 NUTF2 OLIG3 PHF21A PIAS2 PICK1 PSMB1 PSORS1C2 PSTPIP1 PTH2R QARS1 RAD54L2 RBM7 RIN1 RPP30 RPRD1B RSPH9 RUSC1 SCNM1 SMAD4 SMYD1 SUOX SYTL4 TBC1D22B TCP11L1 TESC TRAF4 TRAPPC5 USHBP1
Entrez ID		94121	10363
HPRD ID		06735	16116
Ensembl ID		ENSG00000102362	ENSG00000140382
Uniprot IDs		A0A024RCF8 A8K973 B2R7R4 Q71SF7 Q96C24	B4DMG1 Q9NP66
PDB IDs		2CSZ 3FDW 5X6T
Enriched GO Terms of Interacting Partners?
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