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STXBP1 and PLD1
Data Source:
HPRD
(in vitro, in vivo)
STXBP1
PLD1
Description
syntaxin binding protein 1
phospholipase D1
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Cytoskeleton
Plasma Membrane
Secretory Granule
Axon
Platelet Alpha Granule
Protein-containing Complex
Phagocytic Vesicle
Perinuclear Region Of Cytoplasm
Presynaptic Active Zone Membrane
Extracellular Exosome
Postsynapse
Glutamatergic Synapse
Golgi Membrane
Lysosomal Membrane
Endosome
Endoplasmic Reticulum Membrane
Golgi Apparatus
Plasma Membrane
Membrane
Apical Plasma Membrane
Endocytic Vesicle
Late Endosome Membrane
Specific Granule Membrane
Perinuclear Region Of Cytoplasm
Tertiary Granule Membrane
Cholinergic Synapse
Molecular Function
SNARE Binding
RNA Binding
Protein Binding
Syntaxin-1 Binding
Protein Kinase Binding
Protein Domain Specific Binding
Syntaxin Binding
Identical Protein Binding
Phospholipase Binding
Protein N-terminus Binding
Phospholipase D Activity
Protein Binding
Phosphatidylinositol Binding
N-acylphosphatidylethanolamine-specific Phospholipase D Activity
Biological Process
Platelet Degranulation
Developmental Process Involved In Reproduction
Intracellular Protein Transport
Vesicle Docking Involved In Exocytosis
Neurotransmitter Secretion
Neuromuscular Synaptic Transmission
Axon Target Recognition
Regulation Of Synaptic Vesicle Priming
Glutamate Secretion
Synaptic Vesicle Priming
Synaptic Vesicle Maturation
Vesicle-mediated Transport
Negative Regulation Of Protein-containing Complex Assembly
Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane
Negative Regulation Of Synaptic Transmission, GABAergic
Response To Estradiol
SNARE Complex Assembly
Regulation Of SNARE Complex Assembly
Positive Regulation Of Mast Cell Degranulation
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Calcium Ion-dependent Exocytosis
Protein Stabilization
Long-term Synaptic Depression
Platelet Aggregation
Cellular Response To Interferon-gamma
Protein Localization To Plasma Membrane
Presynaptic Dense Core Vesicle Exocytosis
Positive Regulation Of Vesicle Docking
Positive Regulation Of Glutamate Secretion, Neurotransmission
Regulation Of Acrosomal Vesicle Exocytosis
Phosphatidic Acid Biosynthetic Process
Chemotaxis
Small GTPase Mediated Signal Transduction
Ras Protein Signal Transduction
Lipid Catabolic Process
Regulation Of Microvillus Assembly
Neutrophil Degranulation
Positive Regulation Of Translation
Inositol Lipid-mediated Signaling
Cell Motility
Regulation Of Synaptic Vesicle Cycle
Pathways
Regulation of insulin secretion
Neurexins and neuroligins
Synthesis of PG
Synthesis of PA
Role of phospholipids in phagocytosis
Neutrophil degranulation
Drugs
Choline
LAX-101
Choline salicylate
Diseases
Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS
Body size at age 10 (
32376654
)
Whole brain grey matter density (
31530798
)
Cerebrospinal fluid AB1-42 levels (
29274321
)
Eosinophil counts (
32888494
)
Red cell distribution width (
32888494
27863252
28957414
)
Reticulocyte fraction of red cells (
32888494
)
Interacting Genes
34 interacting genes:
APBA1
APBA2
APP
BRME1
CDK5
CDK5R1
CENPP
DOC2A
DOC2B
HGS
MAPK1
MAPT
MEOX2
MTDH
MTNR1A
NEFH
NEFM
PLD1
PLD2
PRKCA
PRKCB
PRKCG
SPICE1
SPTBN1
SQSTM1
STX19
STX1A
STX1B
STX2
STX3
STX5
SYTL4
TRIM38
USO1
26 interacting genes:
ACTA1
ACTB
ACTG1
ARF1
ARF6
ARIH1
BIN1
CAV1
CDC42
EGFR
EGLN1
HIF1A
PEA15
PIP5K1A
PKN1
PKN3
PRKCA
RAC1
RALA
RHEB
RHOA
RHOG
SNCA
SRC
STXBP1
VHL
Entrez ID
6812
5337
HPRD ID
04235
03855
Ensembl ID
ENSG00000136854
ENSG00000075651
Uniprot IDs
P61764
Q13393
Q59EA4
PDB IDs
6L03
6U8Z
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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