RECQL5 and TOP3B

Data Source:
HPRD (in vivo)

		RECQL5	TOP3B
Description		RecQ like helicase 5	DNA topoisomerase III beta
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol RNA Polymerase II, Holoenzyme	Condensed Chromosome Nucleus
	Molecular Function	RNA Polymerase II Complex Binding Nucleic Acid Binding DNA Helicase Activity ATP Binding Four-way Junction Helicase Activity 3'-5' DNA Helicase Activity	DNA Binding RNA Binding DNA Topoisomerase Activity DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity Protein Binding
	Biological Process	Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination DNA Metabolic Process DNA Replication DNA Unwinding Involved In DNA Replication DNA Repair DNA Recombination DNA Duplex Unwinding Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Cellular Response To Drug Cell Division Chromosome Separation Cellular Response To Camptothecin Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Negative Regulation Of Double-strand Break Repair Via Homologous Recombination	DNA Topological Change Chromosome Segregation
Pathways
Drugs
Diseases
GWAS		Deep white matter hyperintensities ( 32517579) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Periventricular white matter hyperintensities ( 32517579)	Attention function in attention deficit hyperactive disorder ( 26174813) Bipolar disorder ( 31043756) Diastolic blood pressure ( 29208002) Response to selective serotonin reuptake inhibitors in depression ( 27622933)
Interacting Genes		20 interacting genes: ADCY10P1 ALDH7A1 BNIPL CREB1 CUX1 DDX42 EEF1G ITGB3BP MAPK8IP1 MRE11 MTSS1 MUS81 NBN PLK1 RAD50 RAD51 STAMBP TIMP1 TOP3A TOP3B	24 interacting genes: ADAMTSL4 AXIN2 BHLHB9 C1QBP CENPF CHD8 CHIC2 CIAO1 FASTK FBLN5 GRN KANK2 KRTAP4-12 MID2 PNMA2 RECQL5 SNRPB SPRED2 SSX2IP TRIM41 UPF2 ZFPM1 ZNF250 ZNF408
Entrez ID		9400	8940
HPRD ID		04806	04662
Ensembl ID		ENSG00000108469	ENSG00000100038
Uniprot IDs		A0A024R8M9 A0A024R8S8 B3KQK2 O94762 Q8WYH5	A0A024R1C2 A8K4N2 O95985
PDB IDs		4BK0 5LB3 5LB5 5LB8 5LBA	5GVC 5GVE
Enriched GO Terms of Interacting Partners?
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