TOP3B and FBLN5

Data Source:
HPRD (two hybrid)

		TOP3B	FBLN5
Description		DNA topoisomerase III beta	fibulin 5
Image			No pdb structure
GO Annotations	Cellular Component	Condensed Chromosome Nucleus	Extracellular Region Extracellular Space Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome Elastic Fiber
	Molecular Function	DNA Binding RNA Binding DNA Topoisomerase Activity DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity Protein Binding	Integrin Binding Calcium Ion Binding Protein Binding Protein C-terminus Binding Extracellular Matrix Constituent Conferring Elasticity Protein Homodimerization Activity
	Biological Process	DNA Topological Change Chromosome Segregation	Cell-matrix Adhesion Extracellular Matrix Organization Protein Localization To Cell Surface Secretion Elastic Fiber Assembly Regulation Of Removal Of Superoxide Radicals
Pathways			Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs
Diseases			Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
GWAS		Attention function in attention deficit hyperactive disorder ( 26174813) Bipolar disorder ( 31043756) Diastolic blood pressure ( 29208002) Response to selective serotonin reuptake inhibitors in depression ( 27622933)	Diastolic blood pressure ( 30578418) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Heel bone mineral density ( 30598549) Height ( 25429064 31562340 18391951) Optic disc size ( 31809533) Pulse pressure ( 27841878 30578418) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		24 interacting genes: ADAMTSL4 AXIN2 BHLHB9 C1QBP CENPF CHD8 CHIC2 CIAO1 FASTK FBLN5 GRN KANK2 KRTAP4-12 MID2 PNMA2 RECQL5 SNRPB SPRED2 SSX2IP TRIM41 UPF2 ZFPM1 ZNF250 ZNF408	12 interacting genes: ATN1 GFI1B LOXL1 LPA MEOX2 NUFIP2 OTX1 PAXIP1 PRNP SOD3 TOP3B TRIP13
Entrez ID		8940	10516
HPRD ID		04662	05204
Ensembl ID		ENSG00000100038	ENSG00000140092
Uniprot IDs		A0A024R1C2 A8K4N2 O95985	A0A024R6G3 Q9UBX5
PDB IDs		5GVC 5GVE
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?