TOP3B and ZFPM1

Data Source:
HPRD (two hybrid)

		TOP3B	ZFPM1
Description		DNA topoisomerase III beta	zinc finger protein, FOG family member 1
Image
GO Annotations	Cellular Component	Condensed Chromosome Nucleus	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Transcription Repressor Complex
	Molecular Function	DNA Binding RNA Binding DNA Topoisomerase Activity DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding RNA Polymerase II Activating Transcription Factor Binding Transcription Corepressor Activity Protein Binding Transcription Factor Binding Metal Ion Binding
	Biological Process	DNA Topological Change Chromosome Segregation	Negative Regulation Of Transcription By RNA Polymerase II T-helper Cell Lineage Commitment Outflow Tract Morphogenesis Atrioventricular Valve Morphogenesis Mitral Valve Formation Tricuspid Valve Formation Heart Development Blood Coagulation Regulation Of Definitive Erythrocyte Differentiation Cell Differentiation Erythrocyte Differentiation Megakaryocyte Differentiation Platelet Formation Granulocyte Differentiation Negative Regulation Of Protein Binding Regulation Of Chemokine Production Negative Regulation Of Interleukin-4 Production Positive Regulation Of Interferon-gamma Production Embryonic Hemopoiesis Megakaryocyte Development Negative Regulation Of Fat Cell Differentiation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cardiac Muscle Tissue Morphogenesis Definitive Erythrocyte Differentiation Primitive Erythrocyte Differentiation Negative Regulation Of Mast Cell Differentiation Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Transcriptional Activation By Promoter-enhancer Looping
Pathways			RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Attention function in attention deficit hyperactive disorder ( 26174813) Bipolar disorder ( 31043756) Diastolic blood pressure ( 29208002) Response to selective serotonin reuptake inhibitors in depression ( 27622933)	Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Bone mineral accretion in asthma (oral corticosteroid dose interaction) ( 26025128) Calcium levels ( 29403010) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Hair color ( 26926045) Hematocrit ( 32888494 27863252) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 29083408 32154731) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Platelet count ( 29403010 32888494 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) PR interval ( 32439900) Red blood cell count ( 32888494 27863252) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Sum eosinophil basophil counts ( 27863252) Testicular germ cell tumor ( 28604728 28604732 26503584) Vascular endothelial growth factor levels ( 26910538) White blood cell count (basophil) ( 29403010 27863252)
Interacting Genes		24 interacting genes: ADAMTSL4 AXIN2 BHLHB9 C1QBP CENPF CHD8 CHIC2 CIAO1 FASTK FBLN5 GRN KANK2 KRTAP4-12 MID2 PNMA2 RECQL5 SNRPB SPRED2 SSX2IP TRIM41 UPF2 ZFPM1 ZNF250 ZNF408	6 interacting genes: CTBP2 GATA1 GATA2 GIPC1 GSK3B TOP3B
Entrez ID		8940	161882
HPRD ID		04662	11800
Ensembl ID		ENSG00000100038	ENSG00000179588
Uniprot IDs		A0A024R1C2 A8K4N2 O95985	Q8IX07
PDB IDs		5GVC 5GVE	2XU7
Enriched GO Terms of Interacting Partners?
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