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TOP3B and AXIN2
Data Source:
BioGRID
(two hybrid)
TOP3B
AXIN2
Description
DNA topoisomerase III beta
axin 2
Image
No pdb structure
GO Annotations
Cellular Component
Condensed Chromosome
Nucleus
Nucleus
Cytoplasm
Centrosome
Cytosol
Beta-catenin Destruction Complex
Molecular Function
DNA Binding
RNA Binding
DNA Topoisomerase Activity
DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity
Protein Binding
Protein Binding
Beta-catenin Binding
Enzyme Binding
Ubiquitin Protein Ligase Binding
I-SMAD Binding
Biological Process
DNA Topological Change
Chromosome Segregation
Somitogenesis
Positive Regulation Of Protein Phosphorylation
Intramembranous Ossification
Secondary Heart Field Specification
Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis
Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Cell Death
Wnt Signaling Pathway
Bone Mineralization
Regulation Of Mismatch Repair
Cellular Protein Localization
Odontogenesis
Maintenance Of DNA Repeat Elements
Negative Regulation Of Osteoblast Differentiation
MRNA Stabilization
Regulation Of Chondrocyte Development
Regulation Of Centromeric Sister Chromatid Cohesion
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Beta-catenin-TCF Complex Assembly
Pathways
TCF dependent signaling in response to WNT
Binding of TCF/LEF:CTNNB1 to target gene promoters
Degradation of AXIN
Ub-specific processing proteases
Drugs
Diseases
Tooth agenesis; Hypodontia
Oligodontia-colorectal cancer syndrome
GWAS
Attention function in attention deficit hyperactive disorder (
26174813
)
Bipolar disorder (
31043756
)
Diastolic blood pressure (
29208002
)
Response to selective serotonin reuptake inhibitors in depression (
27622933
)
Blond vs. brown/black hair color (
30531825
)
Heel bone mineral density (
30598549
28869591
)
Height (
31562340
)
Refractive error (
32231278
)
Interacting Genes
24 interacting genes:
ADAMTSL4
AXIN2
BHLHB9
C1QBP
CENPF
CHD8
CHIC2
CIAO1
FASTK
FBLN5
GRN
KANK2
KRTAP4-12
MID2
PNMA2
RECQL5
SNRPB
SPRED2
SSX2IP
TRIM41
UPF2
ZFPM1
ZNF250
ZNF408
52 interacting genes:
AMOT
ANKRD6
AP1M1
APC
APC2
BARD1
BTRC
BYSL
C2orf68
CAPN7
CCDC112
CHIC2
CSNK1E
CTAG2
CTNNB1
CWF19L2
ELOA
FAM161A
FBP1
FBP2
GSK3B
HEMGN
HOXB5
KCNK12
KIFC3
KRTAP10-10
KRTAP10-8
KRTAP4-5
KRTAP9-2
LNX1
MCRS1
PPP2R5A
PRDX1
PSMB2
RANGAP1
SCNM1
SMAD1
SMAD3
SMAD7
STX11
TCEA2
TCEANC
TGFB1
TOP3B
TSGA10
TXLNA
TXLNB
ZNF124
ZNF189
ZNF417
ZNF587
ZNF648
Entrez ID
8940
8313
HPRD ID
04662
04935
Ensembl ID
ENSG00000100038
ENSG00000168646
Uniprot IDs
A0A024R1C2
A8K4N2
O95985
E7ES00
Q9Y2T1
PDB IDs
5GVC
5GVE
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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