RECQL5 and MUS81

Data Source:
BioGRID (pull down)

		RECQL5	MUS81
Description		RecQ like helicase 5	MUS81 structure-specific endonuclease subunit
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol RNA Polymerase II, Holoenzyme	Nucleus Nucleoplasm Nucleolus Holliday Junction Resolvase Complex
	Molecular Function	RNA Polymerase II Complex Binding Nucleic Acid Binding DNA Helicase Activity ATP Binding Four-way Junction Helicase Activity 3'-5' DNA Helicase Activity	DNA Binding Protein Binding Metal Ion Binding 3'-flap Endonuclease Activity
	Biological Process	Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination DNA Metabolic Process DNA Replication DNA Unwinding Involved In DNA Replication DNA Repair DNA Recombination DNA Duplex Unwinding Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Cellular Response To Drug Cell Division Chromosome Separation Cellular Response To Camptothecin Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Negative Regulation Of Double-strand Break Repair Via Homologous Recombination	Resolution Of Meiotic Recombination Intermediates Double-strand Break Repair Via Break-induced Replication DNA Catabolic Process, Endonucleolytic DNA Repair Intra-S DNA Damage Checkpoint Osteoblast Proliferation Interstrand Cross-link Repair Response To Intra-S DNA Damage Checkpoint Signaling
Pathways			Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway
Drugs
Diseases
GWAS		Deep white matter hyperintensities ( 32517579) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Periventricular white matter hyperintensities ( 32517579)	Acne (severe) ( 24927181) Breast cancer ( 23535729)
Interacting Genes		20 interacting genes: ADCY10P1 ALDH7A1 BNIPL CREB1 CUX1 DDX42 EEF1G ITGB3BP MAPK8IP1 MRE11 MTSS1 MUS81 NBN PLK1 RAD50 RAD51 STAMBP TIMP1 TOP3A TOP3B	10 interacting genes: CHEK2 CSNK2A1 DDB1 EME1 EME2 RECQL5 SLX1A SLX4 SUMO2 UHRF1
Entrez ID		9400	80198
HPRD ID		04806	09419
Ensembl ID		ENSG00000108469	ENSG00000172732
Uniprot IDs		A0A024R8M9 A0A024R8S8 B3KQK2 O94762 Q8WYH5	Q53ES5 Q96NY9
PDB IDs		4BK0 5LB3 5LB5 5LB8 5LBA	2MC3 2ZIX 4P0P 4P0Q 4P0R 4P0S
Enriched GO Terms of Interacting Partners?
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