TOP3B and CHIC2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TOP3B	CHIC2
Description		DNA topoisomerase III beta	cysteine rich hydrophobic domain 2
Image			No pdb structure
GO Annotations	Cellular Component	Condensed Chromosome Nucleus	Golgi Apparatus Golgi-associated Vesicle Plasma Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	DNA Binding RNA Binding DNA Topoisomerase Activity DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity Protein Binding	Molecular_function Protein Binding
	Biological Process	DNA Topological Change Chromosome Segregation	Biological_process
Pathways
Drugs
Diseases
GWAS		Attention function in attention deficit hyperactive disorder ( 26174813) Bipolar disorder ( 31043756) Diastolic blood pressure ( 29208002) Response to selective serotonin reuptake inhibitors in depression ( 27622933)	Blood pressure ( 21909110) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Metabolite levels ( 23823483) Post bronchodilator FEV1/FVC ratio ( 26634245) Pulse pressure ( 28739976 30487518) Serum metabolite levels (CMS) ( 31636271) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		24 interacting genes: ADAMTSL4 AXIN2 BHLHB9 C1QBP CENPF CHD8 CHIC2 CIAO1 FASTK FBLN5 GRN KANK2 KRTAP4-12 MID2 PNMA2 RECQL5 SNRPB SPRED2 SSX2IP TRIM41 UPF2 ZFPM1 ZNF250 ZNF408	65 interacting genes: ADAMTSL4 AGXT AXIN2 C1QTNF2 CARD10 CATSPER1 CBY2 CDR2 CEP44 CYSRT1 DNAL4 FBLN1 GMCL1 HOXA1 ITSN2 KANK2 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP4-12 KRTAP4-2 KRTAP5-9 KRTAP6-2 LCE1A LCE1C LCE1F LCE2C LCE3A LCE3C LCE3D LCE5A LCN2 LZTS2 MDFI MEOX2 MTUS2 MYF5 MYPOP NBPF19 NDUFB7 NOTCH2NLA OTX1 PLEKHF1 PLEKHF2 PLEKHG4 PNMA1 POU4F2 PPARA REL SCNM1 SDCBP TCF4 TOP3B TUBGCP4 U2AF2 ZNF330 ZNF837
Entrez ID		8940	26511
HPRD ID		04662	10373
Ensembl ID		ENSG00000100038	ENSG00000109220
Uniprot IDs		A0A024R1C2 A8K4N2 O95985	Q9UKJ5
PDB IDs		5GVC 5GVE
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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