RAB9A and TRIM14

Data Source:
BioGRID (two hybrid)

		RAB9A	TRIM14
Description		RAB9A, member RAS oncogene family	tripartite motif containing 14
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GO Annotations	Cellular Component	Lysosome Late Endosome Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Transport Vesicle Phagocytic Vesicle Membrane Trans-Golgi Network Membrane Melanosome Phagocytic Vesicle Extracellular Exosome	Nucleoplasm Cytoplasm Mitochondrial Outer Membrane Cytosol Phagocytic Vesicle
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity
	Biological Process	Protein Transport Rab Protein Signal Transduction Regulation Of Protein Localization Retrograde Transport, Endosome To Golgi Positive Regulation Of Exocytosis Negative Regulation By Host Of Symbiont Molecular Function	Protein Polyubiquitination Regulation Of Gene Expression Positive Regulation Of Autophagy Protein Ubiquitination Regulation Of Protein Localization Negative Regulation Of Viral Transcription Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Transcription, DNA-templated Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways		Retrograde transport at the Trans-Golgi-Network RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs RHOBTB3 ATPase cycle	Interferon gamma signaling
Drugs		Guanosine-5'-Diphosphate
Diseases
GWAS		Red cell distribution width ( 32888494)	Multiple sclerosis ( 31604244)
Interacting Genes		8 interacting genes: BCL3 GDI1 GDI2 PLIN3 RABEPK RHOBTB3 TM9SF2 TRIM14	84 interacting genes: ABCF3 ADAMTS12 ALG13 AP3M1 ATP1B1 ATP1B3 ATP2A2 ATP5PB ATP6V1H BYSL CARD9 CCDC125 CCDC57 CCDC6 CENPC CIB3 CKS1B CSPP1 EIF3G ERCC3 ETFBKMT EXOC8 FAM50B FAT1 GOLGA2 GOLGA6L9 HERC3 HEXIM2 HNRNPF IHO1 ITM2A IVNS1ABP KAT2B KIF3A KIFC3 LAMTOR1 LNX1 MAPRE3 MITD1 MNAT1 MRPL24 MYO15B NCOR1 NDUFA9 NFAT5 NPC2 PCGF6 PDIA6 PHF11 PIM2 PLCG1 POLR1C POLR2G PPP2R3C PRDM6 PRKAB2 PRPF31 PTPN21 RAB5A RAB9A RAD51D RBM33 RLF RNF125 RNF20 SLF2 SMARCB1 SMIM3 SPG21 STK38 TAX1BP1 TMEM167A TRAF2 TSGA10 UBE2B UBE2N UNK VIM WDR35 WRNIP1 ZC4H2 ZFP36L2 ZGPAT ZNF652
Entrez ID		9367	9830
HPRD ID		02236	05948
Ensembl ID		ENSG00000123595	ENSG00000106785
Uniprot IDs		A0A024RBV5 P51151	A0A024R165 Q14142
PDB IDs		1WMS	6JBM
Enriched GO Terms of Interacting Partners?
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