PRDM6 and TRIM14

Data Source:
BioGRID (two hybrid)

		PRDM6	TRIM14
Description		PR/SET domain 6	tripartite motif containing 14
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleoplasm Cytoplasm Mitochondrial Outer Membrane Cytosol Phagocytic Vesicle
	Molecular Function	Protein Binding Methyltransferase Activity Identical Protein Binding Metal Ion Binding	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of Gene Expression Neurogenesis Methylation Negative Regulation Of Smooth Muscle Cell Differentiation	Protein Polyubiquitination Regulation Of Gene Expression Positive Regulation Of Autophagy Protein Ubiquitination Regulation Of Protein Localization Negative Regulation Of Viral Transcription Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Transcription, DNA-templated Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways			Interferon gamma signaling
Drugs
Diseases
GWAS		Body mass index ( 28892062) Coronary artery disease ( 29212778) Diastolic blood pressure ( 27841878 27618447) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 32602732) Heart rate increase in response to exercise ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Male-pattern baldness ( 28196072) Mammographic density (dense area) ( 25342443) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Percent mammographic density ( 25342443) Pulse pressure ( 27841878 27618447) QRS duration ( 25035420) Systolic blood pressure ( 26390057 27841878 27618447 30578418)	Multiple sclerosis ( 31604244)
Interacting Genes		70 interacting genes: ABI2 AGXT AHCYL1 ANKS1A AQP1 ARID5A ATPAF2 ATXN7L2 BAG3 BANF2 BANP C1orf109 CBFA2T2 CBX8 CCDC120 CCDC57 CCHCR1 CCNL1 CEP57L1 COX5B CSTF2 ELOA ENKD1 EXOSC5 FAM214B FAM90A1 FHL2 FOXD4L1 FRS3 FTO GADD45GIP1 GEM GPANK1 GRXCR1 HOXC8 IL16 IQUB KANK2 KAT5 KCTD9 KIFC3 LMO1 LMO2 LONRF1 MYOZ3 NCK2 NEK6 NFKBID PATZ1 PIH1D2 PRKAA2 PTK6 QARS1 RAD51D ROPN1 RUNX1T1 SAMD4A STK16 TCAF1 TEKT4 TLE5 TRIM14 TRMT12 TSGA10 TSGA10IP TSSK3 TTC23 UBASH3A USP54 ZFYVE26	84 interacting genes: ABCF3 ADAMTS12 ALG13 AP3M1 ATP1B1 ATP1B3 ATP2A2 ATP5PB ATP6V1H BYSL CARD9 CCDC125 CCDC57 CCDC6 CENPC CIB3 CKS1B CSPP1 EIF3G ERCC3 ETFBKMT EXOC8 FAM50B FAT1 GOLGA2 GOLGA6L9 HERC3 HEXIM2 HNRNPF IHO1 ITM2A IVNS1ABP KAT2B KIF3A KIFC3 LAMTOR1 LNX1 MAPRE3 MITD1 MNAT1 MRPL24 MYO15B NCOR1 NDUFA9 NFAT5 NPC2 PCGF6 PDIA6 PHF11 PIM2 PLCG1 POLR1C POLR2G PPP2R3C PRDM6 PRKAB2 PRPF31 PTPN21 RAB5A RAB9A RAD51D RBM33 RLF RNF125 RNF20 SLF2 SMARCB1 SMIM3 SPG21 STK38 TAX1BP1 TMEM167A TRAF2 TSGA10 UBE2B UBE2N UNK VIM WDR35 WRNIP1 ZC4H2 ZFP36L2 ZGPAT ZNF652
Entrez ID		93166	9830
HPRD ID		19698	05948
Ensembl ID		ENSG00000061455	ENSG00000106785
Uniprot IDs		Q9NQX0	A0A024R165 Q14142
PDB IDs			6JBM
Enriched GO Terms of Interacting Partners?
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