AIFM1 and XIAP

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		AIFM1	XIAP
Description		apoptosis inducing factor mitochondria associated 1	X-linked inhibitor of apoptosis
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GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Spindle Microtubule
	Molecular Function	DNA Binding Protein Binding NAD(P)H Oxidase H2O2-forming Activity Oxidoreductase Activity, Acting On NAD(P)H Protein Dimerization Activity FAD Binding	Ubiquitin-protein Transferase Activity Protein Binding Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Chromosome Condensation Mitochondrial Respiratory Chain Complex Assembly Positive Regulation Of Apoptotic Process Protein Import Into Mitochondrial Intermembrane Space Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress	Cellular Response To DNA Damage Stimulus Wnt Signaling Pathway Protein Ubiquitination Regulation Of BMP Signaling Pathway Positive Regulation Of Protein Ubiquitination Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Innate Immune Response Regulation Of Inflammatory Response Neuron Apoptotic Process Regulation Of Cell Cycle Copper Ion Homeostasis Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Linear Polyubiquitination
Pathways			Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes SMAC, XIAP-regulated apoptotic response Deactivation of the beta-catenin transactivating complex RIPK1-mediated regulated necrosis Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Regulation of necroptotic cell death Regulation of PTEN localization Regulation of PTEN stability and activity Regulation of the apoptosome activity
Drugs		Flavin adenine dinucleotide MCC	1-[3,3-Dimethyl-2-(2-Methylamino-Propionylamino)-Butyryl]-Pyrrolidine-2-Carboxylic Acid(1,2,3,4-Tetrahydro-Naphthalen-1-Yl)-Amide Dequalinium N-METHYLALANYL-3-METHYLVALYL-4-PHENOXY-N-(1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL)PROLINAMIDE AEG35156
Diseases		Combined oxidative phosphorylation deficiency (COXPD)	Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS		Bipolar disorder ( 31043756)
Interacting Genes		11 interacting genes: CASP3 EIF3G HSPA1A HSPA1B MLH1 NOA1 SETDB1 STC2 TSC22D4 WWC1 XIAP	92 interacting genes: ACVRL1 AFP AIFM1 AKT1 AKT2 BCL2 BIRC5 BOLA1 BOLA2 BOLA2B BRCA1 CASP10 CASP3 CASP7 CASP9 CCNB1 CDC42 CDK1 CHEK1 CKS1B COMMD1 DIABLO DNM2 DTX3 DYNLL2 ELAVL1 ERCC3 FAF1 GCC1 GOLGA2 GSK3B GSPT1 HNRNPA1 HSPA1A HTRA1 HTRA2 IKBKE INPP5D KCNJ6 LONRF1 MAGED1 MAP3K2 MAP3K3 MAP3K7 MCRS1 MDM2 NEK6 NOD1 NOD2 NOTCH1 NTAQ1 PIBF1 PPIH PPM1K QARS1 RAF1 RFC5 RIPK2 RIPK3 RIPK4 RUNX1T1 SEPTIN4 SERTAD1 SQSTM1 SSX2IP STRADB STUB1 TAB1 TAB2 TBK1 TGFBR1 TLE3 TRAF6 TRIM32 TRIM8 TTC23 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2I UBE2J2 UBE2N UBE2V1 UBE2V2 UBE2W VPS37C XAF1
Entrez ID		9131	331
HPRD ID		02161	02094
Ensembl ID		ENSG00000156709	ENSG00000101966
Uniprot IDs		E9PMA0 O95831	B2R9R2 P98170
PDB IDs		1M6I 4BUR 4BV6 4FDC 4LII 5FMH 5FS6 5FS7 5FS8 5FS9 5KVH 5KVI	1C9Q 1F9X 1G3F 1G73 1I3O 1I4O 1I51 1KMC 1NW9 1TFQ 1TFT 2ECG 2JK7 2KNA 2OPY 2OPZ 2POI 2POP 2QRA 2VSL 3CLX 3CM2 3CM7 3EYL 3G76 3HL5 3UW4 3UW5 4EC4 4HY0 4IC2 4IC3 4J3Y 4J44 4J45 4J46 4J47 4J48 4KJU 4KJV 4KMP 4MTZ 4OXC 4WVS 4WVT 4WVU 5C0K 5C0L 5C3H 5C3K 5C7A 5C7B 5C7C 5C7D 5C83 5C84 5M6E 5M6F 5M6H 5M6L 5M6M 5O6T 5OQW 6EY2 6GJW 6QCI
Enriched GO Terms of Interacting Partners?
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