SMC3 and FEZ2

Data Source:
BioGRID (two hybrid)

		SMC3	FEZ2
Description		structural maintenance of chromosomes 3	fasciculation and elongation protein zeta 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Chromatin Lateral Element Nucleoplasm Chromosome Cytosol Cohesin Complex Nuclear Matrix Meiotic Cohesin Complex Nuclear Meiotic Cohesin Complex Mitotic Spindle Pole	Cytoplasm Axon
	Molecular Function	Chromatin Binding Microtubule Motor Activity Protein Binding ATP Binding Mediator Complex Binding Protein Heterodimerization Activity Beta-tubulin Binding Dynein Complex Binding	Protein Binding
	Biological Process	Mitotic Cell Cycle Regulation Of DNA Replication DNA Repair Sister Chromatid Cohesion Stem Cell Population Maintenance Cell Division Meiotic Cell Cycle Mitotic Spindle Assembly	Signal Transduction Nervous System Development Axon Guidance Negative Regulation Of Autophagosome Assembly
Pathways		Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression
Drugs
Diseases		Cornelia de Lange syndrome (CdLS)
GWAS		Acute respiratory distress syndrome in sepsis ( 31982041) Lumbar spine bone mineral density (integral) ( 27476799) Metabolite levels ( 23823483)	Apolipoprotein A1 levels ( 32203549) Intraocular pressure ( 29617998) Metabolite levels ( 23823483) Offspring birth weight ( 31043758)
Interacting Genes		18 interacting genes: APC CEP63 DISC1 ESCO2 ESR1 FEZ1 FEZ2 KIFAP3 MTNR1B MXD1 MXD3 MXD4 MXI1 RPGR SMC1A SMC1B SUMO2 TRAF3IP1	18 interacting genes: BRD1 CLASP2 DRAP1 FEZ1 KPNA2 NEK1 PDCD7 PRKCZ RAB3GAP1 RAI14 SAP30L SCOC SMC3 TBC1D25 TEDC2 TLK2 WWC1 ZNF251
Entrez ID		9126	9637
HPRD ID		05829	09213
Ensembl ID		ENSG00000108055	ENSG00000171055
Uniprot IDs		Q9UQE7	Q9UHY8
PDB IDs		6WG3 6WG4 6WG6 6WGE
Enriched GO Terms of Interacting Partners?
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