SMC3 and KIFAP3

Data Source:
BioGRID (two hybrid, pull down)
HPRD (in vitro, two hybrid)

		SMC3	KIFAP3
Description		structural maintenance of chromosomes 3	kinesin associated protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Chromatin Lateral Element Nucleoplasm Chromosome Cytosol Cohesin Complex Nuclear Matrix Meiotic Cohesin Complex Nuclear Meiotic Cohesin Complex Mitotic Spindle Pole	Condensed Nuclear Chromosome Endoplasmic Reticulum Golgi Apparatus Centrosome Cytosol Spindle Microtubule Cilium Axoneme Microtubule Cytoskeleton Kinesin II Complex Photoreceptor Connecting Cilium Ciliary Transition Zone Ciliary Basal Body Ciliary Tip Periciliary Membrane Compartment
	Molecular Function	Chromatin Binding Microtubule Motor Activity Protein Binding ATP Binding Mediator Complex Binding Protein Heterodimerization Activity Beta-tubulin Binding Dynein Complex Binding	Protein Binding Kinesin Binding Protein Phosphatase Binding Intraciliary Transport Particle B Binding
	Biological Process	Mitotic Cell Cycle Regulation Of DNA Replication DNA Repair Sister Chromatid Cohesion Stem Cell Population Maintenance Cell Division Meiotic Cell Cycle Mitotic Spindle Assembly	Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Microtubule-based Process Microtubule-based Movement Signal Transduction Negative Regulation Of Cell Population Proliferation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Intraciliary Transport Involved In Cilium Assembly Negative Regulation Of Apoptotic Process Cilium Organization Positive Regulation Of Calcium-dependent Cell-cell Adhesion Protein-containing Complex Assembly Plus-end-directed Vesicle Transport Along Microtubule
Pathways		Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression	Translocation of SLC2A4 (GLUT4) to the plasma membrane MHC class II antigen presentation Intraflagellar transport COPI-dependent Golgi-to-ER retrograde traffic Kinesins Kinesins
Drugs
Diseases		Cornelia de Lange syndrome (CdLS)
GWAS		Acute respiratory distress syndrome in sepsis ( 31982041) Lumbar spine bone mineral density (integral) ( 27476799) Metabolite levels ( 23823483)	Acute anterior uveitis in ankylosing spondylitis ( 32492107) Adverse response to drug ( 30420678) Amyotrophic lateral sclerosis ( 19451621) Atrial fibrillation ( 28416818) L-selectin levels ( 25576479) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		18 interacting genes: APC CEP63 DISC1 ESCO2 ESR1 FEZ1 FEZ2 KIFAP3 MTNR1B MXD1 MXD3 MXD4 MXI1 RPGR SMC1A SMC1B SUMO2 TRAF3IP1	33 interacting genes: APC AR C19orf44 CCSER2 DHX37 DISC1 GTSE1 HOXB5 KANK2 KIF3B MAP3K10 MAP3K11 MARK2 MEST MINK1 MOS MYPOP NAA10 NAA11 NAV1 NCF2 NIPSNAP3A NUDT21 PARD6G PEX19 PRNP RAP1GDS1 RBFOX1 RBM14 RPGR RTP5 SMC3 SRC
Entrez ID		9126	22920
HPRD ID		05829	03499
Ensembl ID		ENSG00000108055	ENSG00000075945
Uniprot IDs		Q9UQE7	Q92845
PDB IDs		6WG3 6WG4 6WG6 6WGE
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?