SMC3 and MXD3

Data Source:
BioGRID (two hybrid, pull down)

		SMC3	MXD3
Description		structural maintenance of chromosomes 3	MAX dimerization protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Chromatin Lateral Element Nucleoplasm Chromosome Cytosol Cohesin Complex Nuclear Matrix Meiotic Cohesin Complex Nuclear Meiotic Cohesin Complex Mitotic Spindle Pole	Chromatin Nucleus
	Molecular Function	Chromatin Binding Microtubule Motor Activity Protein Binding ATP Binding Mediator Complex Binding Protein Heterodimerization Activity Beta-tubulin Binding Dynein Complex Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Protein Dimerization Activity
	Biological Process	Mitotic Cell Cycle Regulation Of DNA Replication DNA Repair Sister Chromatid Cohesion Stem Cell Population Maintenance Cell Division Meiotic Cell Cycle Mitotic Spindle Assembly	Regulation Of Transcription By RNA Polymerase II
Pathways		Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression
Drugs
Diseases		Cornelia de Lange syndrome (CdLS)
GWAS		Acute respiratory distress syndrome in sepsis ( 31982041) Lumbar spine bone mineral density (integral) ( 27476799) Metabolite levels ( 23823483)	Activated partial thromboplastin time ( 22703881) Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Diastolic blood pressure ( 30224653) Lymphocyte percentage of white cells ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Obesity-related traits ( 23251661) Platelet count ( 32888494) Plateletcrit ( 32888494) Serum uric acid levels ( 30993211) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		18 interacting genes: APC CEP63 DISC1 ESCO2 ESR1 FEZ1 FEZ2 KIFAP3 MTNR1B MXD1 MXD3 MXD4 MXI1 RPGR SMC1A SMC1B SUMO2 TRAF3IP1	13 interacting genes: CYSRT1 KRT31 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP3-3 MAGEA11 MAX NBPF19 NOTCH2NLA NUP62 SMC3 TFIP11
Entrez ID		9126	83463
HPRD ID		05829	14791
Ensembl ID		ENSG00000108055	ENSG00000213347
Uniprot IDs		Q9UQE7	A0A024R7S0 Q9BW11
PDB IDs		6WG3 6WG4 6WG6 6WGE
Enriched GO Terms of Interacting Partners?
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