TRADD and TMC8

Data Source:
BioGRID (protein complementation assay)

		TRADD	TMC8
Description		TNFRSF1A associated via death domain	transmembrane channel like 8
Image			No pdb structure
GO Annotations	Cellular Component	Tumor Necrosis Factor Receptor Superfamily Complex Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Death-inducing Signaling Complex Receptor Complex Membrane Raft	Extracellular Space Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Integral Component Of Plasma Membrane Nuclear Membrane Extracellular Exosome
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Tumor Necrosis Factor Receptor Binding Protein Binding Kinase Binding Identical Protein Binding Protein-containing Complex Binding Death Domain Binding	Protein Binding Mechanosensitive Ion Channel Activity Tumor Necrosis Factor Binding Protein Sequestering Activity
	Biological Process	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cell Migration Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Inflammatory Response Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Hair Follicle Development Cellular Response To Tumor Necrosis Factor Death-inducing Signaling Complex Assembly Extrinsic Apoptotic Signaling Pathway Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Regulation Of Cell Growth Negative Regulation Of Protein-containing Complex Assembly Negative Regulation Of Protein Binding Ion Transmembrane Transport Zinc Ion Homeostasis Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Regulation of necroptotic cell death Dimerization of procaspase-8 TNF signaling Defective RIPK1-mediated regulated necrosis
Drugs
Diseases			Epidermodysplasia verruciformis
GWAS			Glycated hemoglobin levels ( 29170429) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494 27863252)
Interacting Genes		24 interacting genes: APBB2 BCL10 BIRC2 CNTRL DAPK1 FADD FAS HIPK2 KRT14 KRT18 NGFR PPP2R1A RIPK1 STAT1 TMC8 TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF21 TNFRSF25 TRAF1 TRAF2 TRAF3 TRPC4AP	1 interacting genes: TRADD
Entrez ID		8717	147138
HPRD ID		04610	08387
Ensembl ID		ENSG00000102871	ENSG00000167895
Uniprot IDs		Q15628	A0A024R8N8 B3KXZ8 Q8IU68
PDB IDs		1F2H 1F3V 5XME 6AC0
Enriched GO Terms of Interacting Partners?
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