CARD11 and RNF181

Data Source:
BioGRID (fluorescent resonance energy transfer, affinity chromatography technology)

		CARD11	RNF181
Description		caspase recruitment domain family member 11	ring finger protein 181
Image			No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Cytoplasm Cytosol Plasma Membrane CBM Complex Membrane Raft Extracellular Exosome	Cytoplasm
	Molecular Function	Guanylate Kinase Activity Protein Binding CARD Domain Binding	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Stimulatory C-type Lectin Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling B Cell Differentiation Positive Regulation Of B Cell Proliferation T Cell Costimulation Positive Regulation Of Interleukin-2 Production Fc-epsilon Receptor Signaling Pathway TORC1 Signaling B Cell Proliferation Positive Regulation Of T Cell Proliferation Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Thymic T Cell Selection Regulation Of B Cell Differentiation Regulation Of T Cell Differentiation GMP Metabolic Process GDP Metabolic Process Homeostasis Of Number Of Cells T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity	Protein Ubiquitination Protein Autoubiquitination
Pathways		Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells Downstream TCR signaling FCERI mediated NF-kB activation FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling	E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Atopic dermatitis ( 23042114) Cadmium levels ( 26025379) Daytime sleep phenotypes ( 27126917) Dupuytren's disease ( 28886342) Intracranial aneurysm ( 29531279) Multiple sclerosis ( 31604244 24076602) Response to fenofibrate (total cholesterol levels) ( 27002377) Ulcerative colitis ( 23128233) White matter integrity ( 23218918)	Prostate cancer ( 21743467)
Interacting Genes		15 interacting genes: BCL10 IKBKG MAP3K7 MAP4K1 PDPK1 PPP2CA PPP2R1A PRKCB PRKCQ RNF181 SH2D3C SRPK2 TAB1 WDR1 ZAP70	22 interacting genes: BCL10 BIRC2 BTG1 CARD11 CLK4 MRPS6 NPY5R PEG10 RBCK1 TRIM24 TRIM8 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2U VPS11 ZMYND10
Entrez ID		84433	51255
HPRD ID		06234	14236
Ensembl ID		ENSG00000198286	ENSG00000168894
Uniprot IDs		A0A024R854 Q8TES3 Q9BXL7	Q9P0P0
PDB IDs		4JUP 4LWD
Enriched GO Terms of Interacting Partners?
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