Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
IKBKG and NFKBIA
Data Source:
BioGRID
(enzymatic study)
HPRD
(in vitro)
IKBKG
NFKBIA
Description
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
NFKB inhibitor alpha
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Spindle Pole
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
IkappaB Kinase Complex
Protein-containing Complex
Mitotic Spindle
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
I-kappaB/NF-kappaB Complex
Molecular Function
Protein Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Protein Homodimerization Activity
Peroxisome Proliferator Activated Receptor Binding
Protein-containing Complex Binding
Metal Ion Binding
Protein Heterodimerization Activity
K63-linked Polyubiquitin Modification-dependent Protein Binding
Linear Polyubiquitin Binding
Transferrin Receptor Binding
Protein Binding
Transcription Factor Binding
Nuclear Localization Sequence Binding
Enzyme Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
NF-kappaB Binding
Biological Process
Activation Of MAPK Activity
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
MyD88-independent Toll-like Receptor Signaling Pathway
Apoptotic Process
Inflammatory Response
Immune Response
Cellular Response To DNA Damage Stimulus
I-kappaB Kinase/NF-kappaB Signaling
JNK Cascade
Response To Virus
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Viral Process
Positive Regulation Of Macroautophagy
Protein Deubiquitination
TRIF-dependent Toll-like Receptor Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Anoikis
Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Stress-activated MAPK Cascade
Establishment Of Vesicle Localization
Protein-containing Complex Assembly
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Negative Regulation Of Neuron Death
Protein Import Into Nucleus
Apoptotic Process
I-kappaB Kinase/NF-kappaB Signaling
Cytoplasmic Sequestering Of NF-kappaB
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Cholesterol Efflux
Negative Regulation Of Lipid Storage
Viral Process
Protein Deubiquitination
Lipopolysaccharide-mediated Signaling Pathway
Negative Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Cellular Protein Metabolic Process
Response To Muramyl Dipeptide
Tumor Necrosis Factor-mediated Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Response To Muscle Stretch
Regulation Of Cell Population Proliferation
Cytoplasmic Sequestering Of Transcription Factor
Negative Regulation Of Apoptotic Process
Response To Exogenous DsRNA
Negative Regulation Of DNA Binding
Negative Regulation Of Myeloid Cell Differentiation
Negative Regulation Of Notch Signaling Pathway
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Inflammatory Response
Cellular Response To Cold
Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway
Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Regulation Of NIK/NF-kappaB Signaling
Pathways
Activation of NF-kappaB in B cells
Activation of NF-kappaB in B cells
ER-Phagosome pathway
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
RIP-mediated NFkB activation via ZBP1
Downstream TCR signaling
FCERI mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
SUMOylation of immune response proteins
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
IKBKB deficiency causes SCID
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
IkBA variant leads to EDA-ID
CLEC7A (Dectin-1) signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Ub-specific processing proteases
Ovarian tumor domain proteases
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Activation of NF-kappaB in B cells
RIP-mediated NFkB activation via ZBP1
Downstream TCR signaling
NF-kB is activated and signals survival
FCERI mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
SUMOylation of immune response proteins
IkBA variant leads to EDA-ID
CLEC7A (Dectin-1) signaling
Ub-specific processing proteases
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
Drugs
AGRO100
Tarenflurbil
Acetylsalicylic acid
Bardoxolone methyl
Astaxanthin
Diseases
Ectodermal dysplasia associated immunodeficiency (EDA-ID), including the following two diseases: NF-kappa-B essential modulator (NEMO) defect; Inhibitor of kappa-B (I-kappa-B) defect
Incontinentia pigmenti
Osteoporosis, lymphedema, anhydrotic ectodermal dysplasia with immunodeficiency (OLEDAID); Ectodermal dysplasia, anhidrotic, with immunodeficiency, osteopetrosis, and lymphedema
Ectodermal dysplasia associated immunodeficiency (EDA-ID), including the following two diseases: NF-kappa-B essential modulator (NEMO) defect; Inhibitor of kappa-B (I-kappa-B) defect
Hodgkin lymphoma
GWAS
Hemoglobin levels (
26366553
)
Asthma (
30929738
32296059
)
Asthma (childhood onset) (
30929738
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Creatine kinase levels (
29403010
)
Eczema (
31361310
)
Hip circumference adjusted for BMI (
25673412
)
Inflammatory skin disease (
25574825
)
Lymphocyte counts (
32888494
27863252
)
Monocyte count (
32888494
)
PR interval (
32439900
)
Psoriasis (
25854761
25903422
20953189
20953190
25574825
23143594
)
Psoriasis vulgaris (
26626624
)
Pulse pressure (
27841878
30578418
)
Systolic blood pressure (
27841878
28739976
30578418
)
White blood cell count (
32888494
)
Interacting Genes
242 interacting genes:
ABCA1
ACBD6
ADAP2
AIP
ALK
AMMECR1L
APRT
ARF4
ARF5
ARF6
ARGLU1
ARHGDIA
ARL6IP4
ARPP19
AVPI1
BCL10
BIRC2
BIRC3
BRME1
C19orf12
CALB1
CALCOCO2
CARD10
CARD11
CARD8
CASP6
CASP8
CCHCR1
CDC37
CDK2
CDKN1A
CETN3
CHUK
CLIC1
CNOT7
COPS3
CPNE2
CREBBP
CUEDC1
CWF19L2
CYLD
DAPK1
DDIT3
DDX19B
DNAJC8
DYNC1LI1
EEF1A1
EGFR
EGLN3
EIF1AX
ENKD1
EPHA4
FADD
FGR
FLT3
FLT4
FRMD8
GADD45G
GADD45GIP1
GCC1
GEMIN2
GFAP
GIT2
GLO1
GNGT1
GPKOW
GRK4
GSK3B
GTF2E1
GUCY1A1
GYG2
H1-0
HBZ
HCLS1
HDDC2
HIF1A
HLA-DQA1
HPCAL1
HPD
HSP90AA1
HSP90AB1
HSPA1A
HSPA4
ID1
ID3
IFIT5
IKBKB
INO80E
IRAK1
IRAK4
ITK
JAK2
JAK3
KANSL2
KIR3DX1
KRT18
KRT8
LCK
LENG8
LGALS2
LMCD1
LPXN
LUC7L2
LZIC
LZTR1
MACROD1
MAFIP
MAP3K14
MAP3K2
MAP3K7
MAPRE1
MCM10
MCM7
MED7
MERTK
MLLT6
MPRIP
MYD88
MYL5
MYO5C
MZT2A
NAP1L5
NCOA3
NECAB3
NFKB1
NFKB2
NFKBIA
NFKBIB
NHP2
NRARP
NRBF2
NTMT1
ODAM
OSBPL10
OSGIN1
PA2G4
PARP1
PCK1
PDCL
PFDN5
PHF7
PIM2
PLEKHJ1
PNMA8A
POLR2B
POLR2D
POLR2E
POLR3A
PPM1B
PRKCB
PRKCI
PRKCQ
PRKD3
PRKN
PRPF18
PSMA3
PSMB5
RAB11A
RAB11B
RAB8A
RALBP1
RBBP8
RBM34
RBM8A
RBP1
RELA
RET
RHOA
RIPK1
RIPK2
RNF11
RNF4
RNF7
ROR2
ROS1
RPL41
RPS12
RPS6KB2
SCLT1
SENP2
SEPTIN9
SGK1
SHTN1
SLU7
SNW1
SRC
SRPK1
SSX2IP
STK25
STX11
SUPT5H
SYT1
TAB1
TAB2
TAB3
TAF7
TANK
TARBP2
TAX1BP1
TBC1D7
TBK1
TCEANC
TCP10L
TCP11
TCP11L1
TEC
TEK
TMA16
TNFAIP3
TNFRSF1A
TNIP1
TNIP2
TPT1
TRAF3IP2
TRIM29
TRIM31
TRIM37
TRIM41
TRIOBP
TRPC4AP
TSLP
TTYH2
TUBG1
TXLNA
TYRO3
UBASH3A
UBB
UBC
UBE2D3
UBE2D4
UBE2I
USP10
USP2
VAMP3
WDR5
WWP1
ZBTB3
ZC3H12A
ZFAND5
ZNF587
ZNF835
ZZZ3
89 interacting genes:
ABL1
ARRB1
ARRB2
ATF4
AURKA
BARD1
BTRC
CAPN1
CAPN2
CD7
CDC34
CHUK
COMMD1
COPS8
CSNK2A1
CUL1
DNAJA3
DYNLL1
EIF2AK2
ELP1
ENKD1
FBXW11
G3BP2
HDAC1
HDAC3
HNRNPA1
HOXA9
HOXB7
HSPB1
IKBKB
IKBKE
IKBKG
IKZF4
ITPK1
JAK2
LCK
LYL1
MAP3K1
MAP3K14
MAP3K2
MAP3K3
MAP3K7
MCM5
MCM7
MED19
NCOR2
NEDD9
NFKB1
NFKB2
NFKBIB
NKIRAS1
NKIRAS2
PIK3R1
PIR
POLR2C
POM121
PRKCA
PRKCI
PSMA2
PSMD3
PTPN1
PTPN13
REL
RELA
RNF115
RPS6KA1
RPS6KA3
RWDD3
SKP1
SLC25A4
SLC25A5
SRC
ST7
SUMO1
SUMO4
TBK1
TCL1A
TNF
TNFSF11
TP53
TUBA1B
UBE2D1
UBE2D2
UBE2D3
UBE2E3
UBE2I
UBE2L3
VCP
ZNF212
Entrez ID
8517
4792
HPRD ID
02217
01235
Ensembl ID
ENSG00000269335
ENSG00000100906
Uniprot IDs
A0A087X1B1
Q9Y6K9
P25963
PDB IDs
2JVX
2JVY
3BRT
3BRV
3CL3
3FX0
4BWN
5AAY
5LDE
6MI3
6MI4
1IKN
1NFI
6TTU
6Y1J
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?