IKBKG and CALCOCO2

Data Source:
BioGRID (two hybrid)

		IKBKG	CALCOCO2
Description		inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	calcium binding and coiled-coil domain 2
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Spindle Pole Nucleus Nucleoplasm Cytoplasm Cytosol IkappaB Kinase Complex Protein-containing Complex Mitotic Spindle	Autophagosome Membrane Nucleus Cytoplasm Autophagosome Cytosol Cytoskeleton Membrane PML Body Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Peroxisome Proliferator Activated Receptor Binding Protein-containing Complex Binding Metal Ion Binding Protein Heterodimerization Activity K63-linked Polyubiquitin Modification-dependent Protein Binding Linear Polyubiquitin Binding Transferrin Receptor Binding	Protein Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Activation Of MAPK Activity Stimulatory C-type Lectin Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent MyD88-independent Toll-like Receptor Signaling Pathway Apoptotic Process Inflammatory Response Immune Response Cellular Response To DNA Damage Stimulus I-kappaB Kinase/NF-kappaB Signaling JNK Cascade Response To Virus Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Viral Process Positive Regulation Of Macroautophagy Protein Deubiquitination TRIF-dependent Toll-like Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Anoikis Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Establishment Of Vesicle Localization Protein-containing Complex Assembly Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Interleukin-1-mediated Signaling Pathway Negative Regulation Of Neuron Death	Viral Process Response To Interferon-gamma Xenophagy Positive Regulation Of Autophagosome Maturation
Pathways		Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells ER-Phagosome pathway NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 Downstream TCR signaling FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 SUMOylation of immune response proteins Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway IKBKB deficiency causes SCID IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) IkBA variant leads to EDA-ID CLEC7A (Dectin-1) signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Ub-specific processing proteases Ovarian tumor domain proteases Interleukin-1 signaling TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Drugs		AGRO100 Tarenflurbil
Diseases		Ectodermal dysplasia associated immunodeficiency (EDA-ID), including the following two diseases: NF-kappa-B essential modulator (NEMO) defect; Inhibitor of kappa-B (I-kappa-B) defect Incontinentia pigmenti Osteoporosis, lymphedema, anhydrotic ectodermal dysplasia with immunodeficiency (OLEDAID); Ectodermal dysplasia, anhidrotic, with immunodeficiency, osteopetrosis, and lymphedema
GWAS		Hemoglobin levels ( 26366553)	Blood protein levels ( 30072576) Chronotype ( 30696823) Type 2 diabetes ( 29358691 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382)
Interacting Genes		242 interacting genes: ABCA1 ACBD6 ADAP2 AIP ALK AMMECR1L APRT ARF4 ARF5 ARF6 ARGLU1 ARHGDIA ARL6IP4 ARPP19 AVPI1 BCL10 BIRC2 BIRC3 BRME1 C19orf12 CALB1 CALCOCO2 CARD10 CARD11 CARD8 CASP6 CASP8 CCHCR1 CDC37 CDK2 CDKN1A CETN3 CHUK CLIC1 CNOT7 COPS3 CPNE2 CREBBP CUEDC1 CWF19L2 CYLD DAPK1 DDIT3 DDX19B DNAJC8 DYNC1LI1 EEF1A1 EGFR EGLN3 EIF1AX ENKD1 EPHA4 FADD FGR FLT3 FLT4 FRMD8 GADD45G GADD45GIP1 GCC1 GEMIN2 GFAP GIT2 GLO1 GNGT1 GPKOW GRK4 GSK3B GTF2E1 GUCY1A1 GYG2 H1-0 HBZ HCLS1 HDDC2 HIF1A HLA-DQA1 HPCAL1 HPD HSP90AA1 HSP90AB1 HSPA1A HSPA4 ID1 ID3 IFIT5 IKBKB INO80E IRAK1 IRAK4 ITK JAK2 JAK3 KANSL2 KIR3DX1 KRT18 KRT8 LCK LENG8 LGALS2 LMCD1 LPXN LUC7L2 LZIC LZTR1 MACROD1 MAFIP MAP3K14 MAP3K2 MAP3K7 MAPRE1 MCM10 MCM7 MED7 MERTK MLLT6 MPRIP MYD88 MYL5 MYO5C MZT2A NAP1L5 NCOA3 NECAB3 NFKB1 NFKB2 NFKBIA NFKBIB NHP2 NRARP NRBF2 NTMT1 ODAM OSBPL10 OSGIN1 PA2G4 PARP1 PCK1 PDCL PFDN5 PHF7 PIM2 PLEKHJ1 PNMA8A POLR2B POLR2D POLR2E POLR3A PPM1B PRKCB PRKCI PRKCQ PRKD3 PRKN PRPF18 PSMA3 PSMB5 RAB11A RAB11B RAB8A RALBP1 RBBP8 RBM34 RBM8A RBP1 RELA RET RHOA RIPK1 RIPK2 RNF11 RNF4 RNF7 ROR2 ROS1 RPL41 RPS12 RPS6KB2 SCLT1 SENP2 SEPTIN9 SGK1 SHTN1 SLU7 SNW1 SRC SRPK1 SSX2IP STK25 STX11 SUPT5H SYT1 TAB1 TAB2 TAB3 TAF7 TANK TARBP2 TAX1BP1 TBC1D7 TBK1 TCEANC TCP10L TCP11 TCP11L1 TEC TEK TMA16 TNFAIP3 TNFRSF1A TNIP1 TNIP2 TPT1 TRAF3IP2 TRIM29 TRIM31 TRIM37 TRIM41 TRIOBP TRPC4AP TSLP TTYH2 TUBG1 TXLNA TYRO3 UBASH3A UBB UBC UBE2D3 UBE2D4 UBE2I USP10 USP2 VAMP3 WDR5 WWP1 ZBTB3 ZC3H12A ZFAND5 ZNF587 ZNF835 ZZZ3	180 interacting genes: ABLIM1 ADSL AKAP17A AMMECR1 AP5B1 APEX2 ARHGEF39 ARHGEF5 ARNT2 ATG5 AXIN1 BAHD1 BCL6B BEX2 CBX8 CCDC120 CCDC185 CCDC33 CCNH CDC7 CELA2B CEP57L1 CHCHD3 CNNM3 CPNE7 CWF19L2 DAXX DAZAP2 DBNDD2 DCTN4 DCX DDIT4L DDX6 DOCK2 DUSP12 DUSP26 EEF1E1 EFHC1 ELOA2 ENKD1 EXOSC5 FAM107A FAM161A FAM168A FAM189A2 FAM214B FAM90A1 FARS2 FASTK FBF1 FBXL18 FKBPL FNDC11 FOXD4L3 FXR2 GABARAPL1 GABARAPL2 GATAD2B GCA GEMIN4 GIT2 GLYCTK HDAC4 HDAC7 HLX HNRNPLL HOXB5 HOXB9 IKBKG IL16 IQUB KANSL1 KAT7 KLHL35 KLHL42 LENG1 LGALS8 LIMS2 LITAF LMF2 LMO2 LMO4 LNX1 LONRF1 LSM4 MAGOHB MAP1LC3C MCM10 METTL17 MID2 MOS MTPAP MVP MXI1 MYH6 MYO6 NAA10 NDN NFU1 ORC5 PCGF1 PEF1 PEG10 PFDN5 PHF1 PIAS4 PLEKHN1 POLI POLR2A PPP1R18 PRKAA2 PRKAB2 PRPF18 PRPF31 PSMA1 PSME4 PTBP1 PTBP2 QARS1 RAB35 RABL6 RBM15 RHPN1 RIN1 RNF11 RPA2 RPL9 RPS27A RTN4IP1 RTP5 RXRB SCAND1 SCNM1 SDCBP SETD5 SHC1 SLC15A3 SMARCD1 SMCP SNRPB SPATA24 SRI STAMBPL1 STK16 TACO1 TBC1D22B TBK1 TBKBP1 TBRG4 TCL1A TEKT3 TENT2 TLE5 TP53RK TRAF2 TRAF4 TRAF6 TSGA10IP TTC23L UBAC2 USP2 VARS1 VPS72 ZBTB4 ZC2HC1C ZNF101 ZNF205 ZNF337 ZNF408 ZNF414 ZNF426 ZNF451 ZNF564 ZNF581 ZNF638 ZNF648 ZNF688 ZNF696 ZNF774 ZNF80
Entrez ID		8517	10241
HPRD ID		02217	06846
Ensembl ID		ENSG00000269335	ENSG00000136436
Uniprot IDs		A0A087X1B1 Q9Y6K9	Q13137
PDB IDs		2JVX 2JVY 3BRT 3BRV 3CL3 3FX0 4BWN 5AAY 5LDE 6MI3 6MI4	2MXP 3VVV 3VVW 4GXL 4HAN 4XKL 5AAQ 5Z7A 5Z7L
Enriched GO Terms of Interacting Partners?
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