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IKBKG and JAK3
Data Source:
BioGRID
(pull down)
IKBKG
JAK3
Description
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
Janus kinase 3
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Spindle Pole
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
IkappaB Kinase Complex
Protein-containing Complex
Mitotic Spindle
Endosome
Cytosol
Cytoskeleton
Plasma Membrane
Molecular Function
Protein Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Protein Homodimerization Activity
Peroxisome Proliferator Activated Receptor Binding
Protein-containing Complex Binding
Metal Ion Binding
Protein Heterodimerization Activity
K63-linked Polyubiquitin Modification-dependent Protein Binding
Linear Polyubiquitin Binding
Transferrin Receptor Binding
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Protein Phosphatase Binding
Biological Process
Activation Of MAPK Activity
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
MyD88-independent Toll-like Receptor Signaling Pathway
Apoptotic Process
Inflammatory Response
Immune Response
Cellular Response To DNA Damage Stimulus
I-kappaB Kinase/NF-kappaB Signaling
JNK Cascade
Response To Virus
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Viral Process
Positive Regulation Of Macroautophagy
Protein Deubiquitination
TRIF-dependent Toll-like Receptor Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Anoikis
Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Stress-activated MAPK Cascade
Establishment Of Vesicle Localization
Protein-containing Complex Assembly
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Negative Regulation Of Neuron Death
MAPK Cascade
Adaptive Immune Response
Negative Regulation Of Dendritic Cell Cytokine Production
Protein Phosphorylation
Enzyme Linked Receptor Protein Signaling Pathway
Tyrosine Phosphorylation Of STAT Protein
Peptidyl-tyrosine Phosphorylation
Cytokine-mediated Signaling Pathway
B Cell Differentiation
Erythrocyte Differentiation
Negative Regulation Of Interleukin-10 Production
Negative Regulation Of Interleukin-12 Production
Intracellular Signal Transduction
Interleukin-15-mediated Signaling Pathway
Interleukin-4-mediated Signaling Pathway
Interleukin-2-mediated Signaling Pathway
Interleukin-7-mediated Signaling Pathway
Interleukin-9-mediated Signaling Pathway
Interleukin-21-mediated Signaling Pathway
Positive Regulation Of T Cell Proliferation
Regulation Of Apoptotic Process
T Cell Homeostasis
Innate Immune Response
Negative Regulation Of FasL Production
Negative Regulation Of T-helper 1 Cell Differentiation
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Negative Regulation Of T Cell Activation
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Regulation Of T Cell Apoptotic Process
Negative Regulation Of Thymocyte Apoptotic Process
Response To Interleukin-2
Response To Interleukin-4
Response To Interleukin-15
Response To Interleukin-9
Pathways
Activation of NF-kappaB in B cells
Activation of NF-kappaB in B cells
ER-Phagosome pathway
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
RIP-mediated NFkB activation via ZBP1
Downstream TCR signaling
FCERI mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
SUMOylation of immune response proteins
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
IKBKB deficiency causes SCID
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
IkBA variant leads to EDA-ID
CLEC7A (Dectin-1) signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Ub-specific processing proteases
Ovarian tumor domain proteases
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Interleukin-7 signaling
Interleukin-7 signaling
RAF/MAP kinase cascade
Interleukin-4 and Interleukin-13 signaling
Interleukin-20 family signaling
Interleukin-15 signaling
Interleukin-15 signaling
Interleukin-9 signaling
Interleukin-2 signaling
Interleukin-21 signaling
Interleukin receptor SHC signaling
Potential therapeutics for SARS
Drugs
AGRO100
Tarenflurbil
2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one
R-348
Tofacitinib
Baricitinib
Fostamatinib
Zanubrutinib
Diseases
Ectodermal dysplasia associated immunodeficiency (EDA-ID), including the following two diseases: NF-kappa-B essential modulator (NEMO) defect; Inhibitor of kappa-B (I-kappa-B) defect
Incontinentia pigmenti
Osteoporosis, lymphedema, anhydrotic ectodermal dysplasia with immunodeficiency (OLEDAID); Ectodermal dysplasia, anhidrotic, with immunodeficiency, osteopetrosis, and lymphedema
T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS
Hemoglobin levels (
26366553
)
Interacting Genes
242 interacting genes:
ABCA1
ACBD6
ADAP2
AIP
ALK
AMMECR1L
APRT
ARF4
ARF5
ARF6
ARGLU1
ARHGDIA
ARL6IP4
ARPP19
AVPI1
BCL10
BIRC2
BIRC3
BRME1
C19orf12
CALB1
CALCOCO2
CARD10
CARD11
CARD8
CASP6
CASP8
CCHCR1
CDC37
CDK2
CDKN1A
CETN3
CHUK
CLIC1
CNOT7
COPS3
CPNE2
CREBBP
CUEDC1
CWF19L2
CYLD
DAPK1
DDIT3
DDX19B
DNAJC8
DYNC1LI1
EEF1A1
EGFR
EGLN3
EIF1AX
ENKD1
EPHA4
FADD
FGR
FLT3
FLT4
FRMD8
GADD45G
GADD45GIP1
GCC1
GEMIN2
GFAP
GIT2
GLO1
GNGT1
GPKOW
GRK4
GSK3B
GTF2E1
GUCY1A1
GYG2
H1-0
HBZ
HCLS1
HDDC2
HIF1A
HLA-DQA1
HPCAL1
HPD
HSP90AA1
HSP90AB1
HSPA1A
HSPA4
ID1
ID3
IFIT5
IKBKB
INO80E
IRAK1
IRAK4
ITK
JAK2
JAK3
KANSL2
KIR3DX1
KRT18
KRT8
LCK
LENG8
LGALS2
LMCD1
LPXN
LUC7L2
LZIC
LZTR1
MACROD1
MAFIP
MAP3K14
MAP3K2
MAP3K7
MAPRE1
MCM10
MCM7
MED7
MERTK
MLLT6
MPRIP
MYD88
MYL5
MYO5C
MZT2A
NAP1L5
NCOA3
NECAB3
NFKB1
NFKB2
NFKBIA
NFKBIB
NHP2
NRARP
NRBF2
NTMT1
ODAM
OSBPL10
OSGIN1
PA2G4
PARP1
PCK1
PDCL
PFDN5
PHF7
PIM2
PLEKHJ1
PNMA8A
POLR2B
POLR2D
POLR2E
POLR3A
PPM1B
PRKCB
PRKCI
PRKCQ
PRKD3
PRKN
PRPF18
PSMA3
PSMB5
RAB11A
RAB11B
RAB8A
RALBP1
RBBP8
RBM34
RBM8A
RBP1
RELA
RET
RHOA
RIPK1
RIPK2
RNF11
RNF4
RNF7
ROR2
ROS1
RPL41
RPS12
RPS6KB2
SCLT1
SENP2
SEPTIN9
SGK1
SHTN1
SLU7
SNW1
SRC
SRPK1
SSX2IP
STK25
STX11
SUPT5H
SYT1
TAB1
TAB2
TAB3
TAF7
TANK
TARBP2
TAX1BP1
TBC1D7
TBK1
TCEANC
TCP10L
TCP11
TCP11L1
TEC
TEK
TMA16
TNFAIP3
TNFRSF1A
TNIP1
TNIP2
TPT1
TRAF3IP2
TRIM29
TRIM31
TRIM37
TRIM41
TRIOBP
TRPC4AP
TSLP
TTYH2
TUBG1
TXLNA
TYRO3
UBASH3A
UBB
UBC
UBE2D3
UBE2D4
UBE2I
USP10
USP2
VAMP3
WDR5
WWP1
ZBTB3
ZC3H12A
ZFAND5
ZNF587
ZNF835
ZZZ3
42 interacting genes:
ALK
APOA1
CD247
CD40
CD81
CDK1
CXCR4
ERBB3
FES
GTF2B
IKBKG
IL2RB
IL2RG
IL4R
IL7R
INPP5D
IRS1
IRS2
JAK1
JAK2
KHDRBS1
KIT
LCK
LNX1
PIK3R1
PRMT5
PTK2B
PTPN2
PTPN6
PTPRC
SH2B2
SHB
SOCS1
SOCS3
STAM
STAM2
STAT3
STAT5A
STAT5B
TIAF1
UHRF2
VIL1
Entrez ID
8517
3718
HPRD ID
02217
02547
Ensembl ID
ENSG00000269335
ENSG00000105639
Uniprot IDs
A0A087X1B1
Q9Y6K9
A0A024R7M7
P52333
PDB IDs
2JVX
2JVY
3BRT
3BRV
3CL3
3FX0
4BWN
5AAY
5LDE
6MI3
6MI4
1YVJ
3LXK
3LXL
3PJC
3ZC6
3ZEP
4HVD
4HVG
4HVH
4HVI
4I6Q
4QPS
4QT1
4RIO
4V0G
4Z16
5LWM
5LWN
5TOZ
5TTS
5TTU
5TTV
5VO6
5W86
5WFJ
6AAK
6DA4
6DB3
6DB4
6DUD
6GL9
6GLA
6GLB
6HZV
6NY4
7C3N
Enriched GO Terms of Interacting Partners
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