PPFIA1 and GIT1

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro, two hybrid)

		PPFIA1	GIT1
Description		PTPRF interacting protein alpha 1	GIT ArfGAP 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Focal Adhesion Presynaptic Active Zone	Mitochondrion Cytosol Focal Adhesion Membrane Calyx Of Held
	Molecular Function	Protein Binding	GTPase Activator Activity Protein Binding Protein-containing Complex Binding Metal Ion Binding
	Biological Process	Cell-matrix Adhesion Signal Transduction Neurotransmitter Secretion Glutamate Secretion Synapse Organization Negative Regulation Of Stress Fiber Assembly Negative Regulation Of Protein Localization To Plasma Membrane	Intramembranous Ossification Brain Development Locomotory Behavior Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Cytokinesis Negative Regulation Of Interleukin-1 Beta Production Positive Regulation Of GTPase Activity Cell Redox Homeostasis Negative Regulation Of Glycolytic Process Ephrin Receptor Signaling Pathway Neuron Development Motor Learning Cellular Response To Lipopolysaccharide Presynaptic Modulation Of Chemical Synaptic Transmission Negative Regulation Of Inflammatory Response To Wounding Regulation Of Synaptic Vesicle Exocytosis
Pathways		Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Receptor-type tyrosine-protein phosphatases	Ephrin signaling Ephrin signaling Activation of RAC1 downstream of NMDARs
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) Lymphocyte counts ( 32888494) Monocyte count ( 32888494)	Adult body size ( 32376654) Brain morphology (MOSTest) ( 32665545)
Interacting Genes		31 interacting genes: AGTPBP1 CAGE1 CAST CCNH CDK18 CEP70 DNAJC5 DTNB DYNC1I2 ELOA ERC1 ERC2 FAM161A GAS8 GIT1 MBIP NCOA2 NDN PPFIA2 PPFIA3 PPFIBP1 PPFIBP2 PPP2R5A PPP2R5D PTPRC PTPRD PTPRF PTPRS TNNT1 TXLNA YWHAG	52 interacting genes: ARHGEF6 ARHGEF7 BARD1 C8orf33 CCDC113 CDC42 CENPU CEP126 CHD3 DDX24 EIF6 ENTR1 GIT2 GRB2 GRK2 GRK3 GRK5 GRK6 HAP1 HMOX2 HTT KIF1A LAMTOR5 LPXN LRIF1 MAN2A2 NEK2 PAK3 PCLO PDPK1 PFDN1 PLCG1 PMF1 PPFIA1 PPFIA2 PPFIA3 PPFIA4 PTK2 PTPRZ1 PXN RAN RGS2 RIF1 SRC SRRT TAB1 TERF1 TGFB1I1 TRIB3 TXNDC9 WDR33 YWHAG
Entrez ID		8500	28964
HPRD ID		11451	06577
Ensembl ID		ENSG00000131626	ENSG00000108262
Uniprot IDs		B3KVS8 Q13136	Q59FC3 Q9Y2X7
PDB IDs		1N7F
Enriched GO Terms of Interacting Partners?
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