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GIT1 and NEK2
Data Source:
BioGRID
(two hybrid)
GIT1
NEK2
Description
GIT ArfGAP 1
NIMA related kinase 2
Image
No pdb structure
GO Annotations
Cellular Component
Mitochondrion
Cytosol
Focal Adhesion
Membrane
Calyx Of Held
Kinetochore
Condensed Chromosome Kinetochore
Condensed Nuclear Chromosome
Spindle Pole
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Centrosome
Cytosol
Microtubule
Midbody
Protein-containing Complex
Molecular Function
GTPase Activator Activity
Protein Binding
Protein-containing Complex Binding
Metal Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Phosphatase Binding
Metal Ion Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Intramembranous Ossification
Brain Development
Locomotory Behavior
Regulation Of G Protein-coupled Receptor Signaling Pathway
Regulation Of Cytokinesis
Negative Regulation Of Interleukin-1 Beta Production
Positive Regulation Of GTPase Activity
Cell Redox Homeostasis
Negative Regulation Of Glycolytic Process
Ephrin Receptor Signaling Pathway
Neuron Development
Motor Learning
Cellular Response To Lipopolysaccharide
Presynaptic Modulation Of Chemical Synaptic Transmission
Negative Regulation Of Inflammatory Response To Wounding
Regulation Of Synaptic Vesicle Exocytosis
Mitotic Sister Chromatid Segregation
G2/M Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Blastocyst Development
Protein Phosphorylation
Chromosome Segregation
Regulation Of Mitotic Nuclear Division
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Positive Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of DNA Binding
Regulation Of Mitotic Centrosome Separation
Protein Autophosphorylation
Spindle Assembly
Centrosome Separation
Cell Division
Meiotic Cell Cycle
Positive Regulation Of Telomerase Activity
Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Mitotic Spindle Assembly
Ciliary Basal Body-plasma Membrane Docking
Negative Regulation Of Centriole-centriole Cohesion
Positive Regulation Of Telomere Capping
Pathways
Ephrin signaling
Ephrin signaling
Activation of RAC1 downstream of NMDARs
APC-Cdc20 mediated degradation of Nek2A
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
AURKA Activation by TPX2
Drugs
5-[(Z)-(5-Chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N,2,4-trimethyl-1H-pyrrole-3-carboxamide
Fostamatinib
Diseases
GWAS
Adult body size (
32376654
)
Brain morphology (MOSTest) (
32665545
)
Red cell distribution width (
32888494
27863252
28957414
)
Interacting Genes
52 interacting genes:
ARHGEF6
ARHGEF7
BARD1
C8orf33
CCDC113
CDC42
CENPU
CEP126
CHD3
DDX24
EIF6
ENTR1
GIT2
GRB2
GRK2
GRK3
GRK5
GRK6
HAP1
HMOX2
HTT
KIF1A
LAMTOR5
LPXN
LRIF1
MAN2A2
NEK2
PAK3
PCLO
PDPK1
PFDN1
PLCG1
PMF1
PPFIA1
PPFIA2
PPFIA3
PPFIA4
PTK2
PTPRZ1
PXN
RAN
RGS2
RIF1
SRC
SRRT
TAB1
TERF1
TGFB1I1
TRIB3
TXNDC9
WDR33
YWHAG
28 interacting genes:
CCDC85A
CDC20
CEP250
CHGA
CSN2
CTNNB1
DCTN1
EDRF1
EIF4A2
FZR1
GIT1
IFT140
IMMT
MAD1L1
MAPK1
MCC
NDC80
NEK11
PDE4DIP
PPP1CA
PPP1CC
PPP1R2
PRKN
PTPRD
SMURF1
SPTBN4
TCF25
TPM3
Entrez ID
28964
4751
HPRD ID
06577
04953
Ensembl ID
ENSG00000108262
ENSG00000117650
Uniprot IDs
Q59FC3
Q9Y2X7
F6U4U2
P51955
PDB IDs
2JAV
2W5A
2W5B
2W5H
2WQO
2XK3
2XK4
2XK6
2XK7
2XK8
2XKC
2XKD
2XKE
2XKF
2XNM
2XNN
2XNO
2XNP
4A4X
4AFE
5M51
5M53
5M55
5M57
6SGD
6SGH
6SGI
6SGK
6SK9
6TM5
Enriched GO Terms of Interacting Partners
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