GIT1 and WDR33

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GIT1	WDR33
Description		GIT ArfGAP 1	WD repeat domain 33
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Cytosol Focal Adhesion Membrane Calyx Of Held	Fibrillar Center Collagen Trimer Nucleus Nucleoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex
	Molecular Function	GTPase Activator Activity Protein Binding Protein-containing Complex Binding Metal Ion Binding	RNA Binding
	Biological Process	Intramembranous Ossification Brain Development Locomotory Behavior Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Cytokinesis Negative Regulation Of Interleukin-1 Beta Production Positive Regulation Of GTPase Activity Cell Redox Homeostasis Negative Regulation Of Glycolytic Process Ephrin Receptor Signaling Pathway Neuron Development Motor Learning Cellular Response To Lipopolysaccharide Presynaptic Modulation Of Chemical Synaptic Transmission Negative Regulation Of Inflammatory Response To Wounding Regulation Of Synaptic Vesicle Exocytosis	MRNA Splicing, Via Spliceosome Postreplication Repair Termination Of RNA Polymerase II Transcription MRNA Polyadenylation MRNA Export From Nucleus Spermatogenesis MRNA 3'-end Processing
Pathways		Ephrin signaling Ephrin signaling Activation of RAC1 downstream of NMDARs	Transport of Mature mRNA Derived from an Intronless Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
Drugs
Diseases
GWAS		Adult body size ( 32376654) Brain morphology (MOSTest) ( 32665545)	Coronary artery calcification ( 23870195) Coronary artery disease ( 29212778) White blood cell count ( 32888494)
Interacting Genes		52 interacting genes: ARHGEF6 ARHGEF7 BARD1 C8orf33 CCDC113 CDC42 CENPU CEP126 CHD3 DDX24 EIF6 ENTR1 GIT2 GRB2 GRK2 GRK3 GRK5 GRK6 HAP1 HMOX2 HTT KIF1A LAMTOR5 LPXN LRIF1 MAN2A2 NEK2 PAK3 PCLO PDPK1 PFDN1 PLCG1 PMF1 PPFIA1 PPFIA2 PPFIA3 PPFIA4 PTK2 PTPRZ1 PXN RAN RGS2 RIF1 SRC SRRT TAB1 TERF1 TGFB1I1 TRIB3 TXNDC9 WDR33 YWHAG	19 interacting genes: CDK4 EEF1G GIT1 KAT7 MIR19A MIR19B1 MIR34B MIR92A2 PFN2 PRMT1 RBM48 SH3GL3 TGFBR1 TP53 UBC UTP14A WWOX ZBTB16 ZHX1
Entrez ID		28964	55339
HPRD ID		06577	11680
Ensembl ID		ENSG00000108262	ENSG00000136709
Uniprot IDs		Q59FC3 Q9Y2X7	Q9C0J8
PDB IDs			6BLY 6BM0 6DNH 6F9N 6FBS 6FUW 6URG 6URO
Enriched GO Terms of Interacting Partners?
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