GIT1 and GRK3

Data Source:
HPRD (in vivo)

		GIT1	GRK3
Description		GIT ArfGAP 1	G protein-coupled receptor kinase 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Cytosol Focal Adhesion Membrane Calyx Of Held	Cytosol Plasma Membrane
	Molecular Function	GTPase Activator Activity Protein Binding Protein-containing Complex Binding Metal Ion Binding	Protein Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Binding ATP Binding Beta-adrenergic Receptor Kinase Activity
	Biological Process	Intramembranous Ossification Brain Development Locomotory Behavior Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Cytokinesis Negative Regulation Of Interleukin-1 Beta Production Positive Regulation Of GTPase Activity Cell Redox Homeostasis Negative Regulation Of Glycolytic Process Ephrin Receptor Signaling Pathway Neuron Development Motor Learning Cellular Response To Lipopolysaccharide Presynaptic Modulation Of Chemical Synaptic Transmission Negative Regulation Of Inflammatory Response To Wounding Regulation Of Synaptic Vesicle Exocytosis	Protein Phosphorylation Signal Transduction G Protein-coupled Receptor Signaling Pathway Receptor Internalization
Pathways		Ephrin signaling Ephrin signaling Activation of RAC1 downstream of NMDARs	G alpha (s) signalling events Cargo recognition for clathrin-mediated endocytosis
Drugs			ATP
Diseases
GWAS		Adult body size ( 32376654) Brain morphology (MOSTest) ( 32665545)
Interacting Genes		52 interacting genes: ARHGEF6 ARHGEF7 BARD1 C8orf33 CCDC113 CDC42 CENPU CEP126 CHD3 DDX24 EIF6 ENTR1 GIT2 GRB2 GRK2 GRK3 GRK5 GRK6 HAP1 HMOX2 HTT KIF1A LAMTOR5 LPXN LRIF1 MAN2A2 NEK2 PAK3 PCLO PDPK1 PFDN1 PLCG1 PMF1 PPFIA1 PPFIA2 PPFIA3 PPFIA4 PTK2 PTPRZ1 PXN RAN RGS2 RIF1 SRC SRRT TAB1 TERF1 TGFB1I1 TRIB3 TXNDC9 WDR33 YWHAG	10 interacting genes: ADRB2 AGTR1 BDKRB2 CCR4 CCR5 CXCR4 GIT1 HSPB1 OPRM1 SMURF1
Entrez ID		28964	157
HPRD ID		06577	00183
Ensembl ID		ENSG00000108262	ENSG00000100077
Uniprot IDs		Q59FC3 Q9Y2X7	A0A024R1D8 P35626 Q8N433
PDB IDs
Enriched GO Terms of Interacting Partners?
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