PPM1D and GLCE

Data Source:
BioGRID (two hybrid)

		PPM1D	GLCE
Description		protein phosphatase, Mg2+/Mn2+ dependent 1D	glucuronic acid epimerase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol	Golgi Membrane Golgi Apparatus Integral Component Of Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Metal Ion Binding Mitogen-activated Protein Kinase Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	Calcium Ion Binding Racemase And Epimerase Activity, Acting On Carbohydrates And Derivatives Protein Homodimerization Activity Heparosan-N-sulfate-glucuronate 5-epimerase Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle DNA Methylation Chromatin Silencing Transcription Initiation From RNA Polymerase II Promoter Protein Phosphorylation Protein Dephosphorylation Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Response To Radiation Response To Bacterium DNA Damage Response, Signal Transduction By P53 Class Mediator Peptidyl-threonine Dephosphorylation Negative Regulation Of Gene Expression, Epigenetic	Heparan Sulfate Proteoglycan Biosynthetic Process Heparin Biosynthetic Process
Pathways		Transcriptional regulation by RUNX2	HS-GAG biosynthesis
Drugs
Diseases
GWAS		Blood urea nitrogen levels ( 31152163)	Blood protein levels ( 30072576 29875488)
Interacting Genes		24 interacting genes: BEX2 CASZ1 CHEK2 DIRAS3 DKK3 EPSTI1 ERRFI1 GLCE H3-3A H3C1 ITIH5 KDM1A LYPD3 MAPK11 MDM2 MRC2 NAT2 NCL NSD3 OSGIN1 RHOBTB2 RPL5 TP53 UBC	11 interacting genes: BAG4 BCAR3 CASP8 ERBB2 ESR1 FBXO7 FGFR2 FGFR4 PAX2 PPM1D RB1CC1
Entrez ID		8493	26035
HPRD ID		05482	07020
Ensembl ID		ENSG00000170836	ENSG00000138604
Uniprot IDs		A0A0S2Z4M2 O15297	O94923
PDB IDs			6HZZ 6I01 6I02
Enriched GO Terms of Interacting Partners?
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