GLCE and PPM1D

Data Source:
BioGRID (two hybrid)

		GLCE	PPM1D
Description		glucuronic acid epimerase	protein phosphatase, Mg2+/Mn2+ dependent 1D
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Integral Component Of Membrane	Nucleus Nucleoplasm Nucleolus Cytosol
	Molecular Function	Calcium Ion Binding Racemase And Epimerase Activity, Acting On Carbohydrates And Derivatives Protein Homodimerization Activity Heparosan-N-sulfate-glucuronate 5-epimerase Activity	Protein Serine/threonine Kinase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Metal Ion Binding Mitogen-activated Protein Kinase Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Heparan Sulfate Proteoglycan Biosynthetic Process Heparin Biosynthetic Process	G2/M Transition Of Mitotic Cell Cycle DNA Methylation Chromatin Silencing Transcription Initiation From RNA Polymerase II Promoter Protein Phosphorylation Protein Dephosphorylation Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Response To Radiation Response To Bacterium DNA Damage Response, Signal Transduction By P53 Class Mediator Peptidyl-threonine Dephosphorylation Negative Regulation Of Gene Expression, Epigenetic
Pathways		HS-GAG biosynthesis	Transcriptional regulation by RUNX2
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488)	Blood urea nitrogen levels ( 31152163)
Interacting Genes		11 interacting genes: BAG4 BCAR3 CASP8 ERBB2 ESR1 FBXO7 FGFR2 FGFR4 PAX2 PPM1D RB1CC1	24 interacting genes: BEX2 CASZ1 CHEK2 DIRAS3 DKK3 EPSTI1 ERRFI1 GLCE H3-3A H3C1 ITIH5 KDM1A LYPD3 MAPK11 MDM2 MRC2 NAT2 NCL NSD3 OSGIN1 RHOBTB2 RPL5 TP53 UBC
Entrez ID		26035	8493
HPRD ID		07020	05482
Ensembl ID		ENSG00000138604	ENSG00000170836
Uniprot IDs		O94923	A0A0S2Z4M2 O15297
PDB IDs		6HZZ 6I01 6I02
Enriched GO Terms of Interacting Partners?
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