PPM1D and CASZ1

Data Source:
BioGRID (two hybrid)

		PPM1D	CASZ1
Description		protein phosphatase, Mg2+/Mn2+ dependent 1D	castor zinc finger 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol	Chromatin Nucleus Nucleoplasm Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Metal Ion Binding Mitogen-activated Protein Kinase Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Metal Ion Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle DNA Methylation Chromatin Silencing Transcription Initiation From RNA Polymerase II Promoter Protein Phosphorylation Protein Dephosphorylation Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Response To Radiation Response To Bacterium DNA Damage Response, Signal Transduction By P53 Class Mediator Peptidyl-threonine Dephosphorylation Negative Regulation Of Gene Expression, Epigenetic	Regulation Of Transcription, DNA-templated Multicellular Organism Development Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Transcriptional regulation by RUNX2
Drugs
Diseases
GWAS		Blood urea nitrogen levels ( 31152163)	Allergic disease (asthma, hay fever or eczema) ( 29679657) Apolipoprotein B levels ( 32203549) Atrial fibrillation ( 30061737 29892015) Beard thickness ( 26926045) Blood pressure ( 21572416) Blood urea nitrogen levels ( 31152163) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Diastolic blood pressure ( 27841878 29403010 28739976 27618447 27618452 25249183 30487518) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163 31015462) Facial morphology ( 31763980) Hypertension ( 25249183 30487518) Ischemic stroke ( 29531354) Ischemic stroke (small-vessel) ( 29531354) LDL cholesterol levels ( 32203549) Lymphocyte counts ( 32888494) Male-pattern baldness ( 28196072) Mean arterial pressure ( 29403010 27618448 30487518) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (antihypertensives) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Microalbuminuria ( 31511532) Monocyte count ( 32888494) Neutrophil count ( 32888494) Pulse pressure ( 27841878 29403010 28739976 30487518 30578418) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Red blood cell count ( 32888494) Resistance to antihypertensive treatment in hypertension ( 31545351) Resistant hypertension ( 31545351) Stroke ( 29531354) Systolic blood pressure ( 19430479 27841878 29403010 28739976 27618452 25249183 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Triglyceride levels ( 32203549) Urinary albumin-to-creatinine ratio ( 26631737 31511532) White blood cell count ( 32888494)
Interacting Genes		24 interacting genes: BEX2 CASZ1 CHEK2 DIRAS3 DKK3 EPSTI1 ERRFI1 GLCE H3-3A H3C1 ITIH5 KDM1A LYPD3 MAPK11 MDM2 MRC2 NAT2 NCL NSD3 OSGIN1 RHOBTB2 RPL5 TP53 UBC	9 interacting genes: APP BAG4 BCAR3 ESR2 PALB2 PPM1D PTPN1 RAF1 WT1
Entrez ID		8493	54897
HPRD ID		05482	07897
Ensembl ID		ENSG00000170836	ENSG00000130940
Uniprot IDs		A0A0S2Z4M2 O15297	B3KRV8 Q86V15
PDB IDs
Enriched GO Terms of Interacting Partners?
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