PPM1D and ITIH5

Data Source:
BioGRID (two hybrid)

		PPM1D	ITIH5
Description		protein phosphatase, Mg2+/Mn2+ dependent 1D	inter-alpha-trypsin inhibitor heavy chain 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol	Collagen-containing Extracellular Matrix
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Metal Ion Binding Mitogen-activated Protein Kinase Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	Serine-type Endopeptidase Inhibitor Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle DNA Methylation Chromatin Silencing Transcription Initiation From RNA Polymerase II Promoter Protein Phosphorylation Protein Dephosphorylation Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Response To Radiation Response To Bacterium DNA Damage Response, Signal Transduction By P53 Class Mediator Peptidyl-threonine Dephosphorylation Negative Regulation Of Gene Expression, Epigenetic	Negative Regulation Of Endopeptidase Activity Hyaluronan Metabolic Process
Pathways		Transcriptional regulation by RUNX2
Drugs
Diseases
GWAS		Blood urea nitrogen levels ( 31152163)	Blood protein levels ( 30072576 29875488) Brain morphology (MOSTest) ( 32665545) Metabolite levels ( 23823483) Planum temporale asymmetry index ( 31887566)
Interacting Genes		24 interacting genes: BEX2 CASZ1 CHEK2 DIRAS3 DKK3 EPSTI1 ERRFI1 GLCE H3-3A H3C1 ITIH5 KDM1A LYPD3 MAPK11 MDM2 MRC2 NAT2 NCL NSD3 OSGIN1 RHOBTB2 RPL5 TP53 UBC	10 interacting genes: BAG4 BRCA1 CHEK2 ESR2 HMMR NOTCH2 PPM1D RAD51 RB1CC1 XRCC3
Entrez ID		8493	80760
HPRD ID		05482	13747
Ensembl ID		ENSG00000170836	ENSG00000123243
Uniprot IDs		A0A0S2Z4M2 O15297	A0A096LP62 C9J2H1 G5E9D8 Q86UX2 Q96JW9
PDB IDs
Enriched GO Terms of Interacting Partners?
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