PPM1D and MRC2

Data Source:
BioGRID (two hybrid)

		PPM1D	MRC2
Description		protein phosphatase, Mg2+/Mn2+ dependent 1D	mannose receptor C type 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol	Focal Adhesion Membrane Integral Component Of Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Metal Ion Binding Mitogen-activated Protein Kinase Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	Protein Binding Collagen Binding Carbohydrate Binding Signaling Receptor Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle DNA Methylation Chromatin Silencing Transcription Initiation From RNA Polymerase II Promoter Protein Phosphorylation Protein Dephosphorylation Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Response To Radiation Response To Bacterium DNA Damage Response, Signal Transduction By P53 Class Mediator Peptidyl-threonine Dephosphorylation Negative Regulation Of Gene Expression, Epigenetic	Osteoblast Differentiation Endocytosis Collagen Catabolic Process
Pathways		Transcriptional regulation by RUNX2	Cross-presentation of soluble exogenous antigens (endosomes) Cross-presentation of soluble exogenous antigens (endosomes)
Drugs
Diseases
GWAS		Blood urea nitrogen levels ( 31152163)	Blood protein levels ( 29875488) Diastolic blood pressure ( 28135244 30578418) Heel bone mineral density ( 30598549) Pulse pressure ( 28135244 30578418) Systolic blood pressure ( 30578418)
Interacting Genes		24 interacting genes: BEX2 CASZ1 CHEK2 DIRAS3 DKK3 EPSTI1 ERRFI1 GLCE H3-3A H3C1 ITIH5 KDM1A LYPD3 MAPK11 MDM2 MRC2 NAT2 NCL NSD3 OSGIN1 RHOBTB2 RPL5 TP53 UBC	13 interacting genes: AKT1 BAG4 BRMS1 ESR2 MTDH NDEL1 PALB2 PAX2 PPM1D PTPN1 RAF1 RB1CC1 XRCC3
Entrez ID		8493	9902
HPRD ID		05482	10094
Ensembl ID		ENSG00000170836	ENSG00000011028
Uniprot IDs		A0A0S2Z4M2 O15297	Q9UBG0
PDB IDs			5AO5 5AO6 5E4K 5E4L 5EW6
Enriched GO Terms of Interacting Partners?
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