DSN1 and KNL1

Data Source:
HPRD (in vivo)

		DSN1	KNL1
Description		DSN1 component of MIS12 kinetochore complex	kinetochore scaffold 1
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GO Annotations	Cellular Component	MIS12/MIND Type Complex Kinetochore Condensed Chromosome Kinetochore Nuclear MIS12/MIND Complex Condensed Nuclear Chromosome Inner Kinetochore Fibrillar Center Extracellular Region Nucleoplasm Nucleolus Cytosol Nuclear Body Azurophil Granule Lumen	Condensed Chromosome Kinetochore Acrosomal Vesicle Nucleus Nucleoplasm Cytosol Nuclear Body
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Mitotic Sister Chromatid Segregation Neutrophil Degranulation Cell Division	Acrosome Assembly Attachment Of Spindle Microtubules To Kinetochore Negative Regulation Of Phosphatase Activity CENP-A Containing Nucleosome Assembly Protein Localization To Kinetochore Cell Division
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Neutrophil degranulation Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Factor VII activity ( 30642921) Hallux valgus ( 32131869)	Anxiety and stress-related disorders ( 31116379)
Interacting Genes		12 interacting genes: AIMP2 APP CBX3 CBX5 HGS KNL1 MIS12 NSL1 PIK3R3 PMF1 SUGT1 ZWINT	6 interacting genes: BUB1 BUB1B DSN1 MIS12 PPP1CA TTK
Entrez ID		79980	57082
HPRD ID		16455	10634
Ensembl ID		ENSG00000149636	ENSG00000137812
Uniprot IDs		A8K3X3 Q9H410	Q8NG31
PDB IDs		5LSI 5LSJ 5LSK	3SI5 4A1G 4NF9 4NFA
Enriched GO Terms of Interacting Partners?
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