KNL1 and MIS12

Data Source:
HPRD (in vitro, in vivo)

		KNL1	MIS12
Description		kinetochore scaffold 1	MIS12 kinetochore complex component
Image
GO Annotations	Cellular Component	Condensed Chromosome Kinetochore Acrosomal Vesicle Nucleus Nucleoplasm Cytosol Nuclear Body	MIS12/MIND Type Complex Condensed Chromosome Kinetochore Nuclear MIS12/MIND Complex Nucleus Cytosol
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Acrosome Assembly Attachment Of Spindle Microtubules To Kinetochore Negative Regulation Of Phosphatase Activity CENP-A Containing Nucleosome Assembly Protein Localization To Kinetochore Cell Division	Mitotic Sister Chromatid Segregation Chromosome Segregation Protein Localization To Kinetochore Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Assembly
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Anxiety and stress-related disorders ( 31116379)	Abstraction and mental flexibility ( 31596458) Metabolite levels ( 23823483)
Interacting Genes		6 interacting genes: BUB1 BUB1B DSN1 MIS12 PPP1CA TTK	10 interacting genes: CBX3 CBX5 DSN1 HSP90AA1 KNL1 NDC80 NSL1 PMF1 SUGT1 ZWINT
Entrez ID		57082	79003
HPRD ID		10634	12379
Ensembl ID		ENSG00000137812	ENSG00000167842
Uniprot IDs		Q8NG31	A8K1M4 Q9H081
PDB IDs		3SI5 4A1G 4NF9 4NFA	5LSJ 5LSK
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?