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KNL1 and TTK
Data Source:
BioGRID
(enzymatic study)
KNL1
TTK
Description
kinetochore scaffold 1
TTK protein kinase
Image
GO Annotations
Cellular Component
Condensed Chromosome Kinetochore
Acrosomal Vesicle
Nucleus
Nucleoplasm
Cytosol
Nuclear Body
Kinetochore
Nucleus
Cytoplasm
Spindle
Membrane
Molecular Function
Protein Binding
Protein Serine/threonine Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Kinetochore Binding
Biological Process
Acrosome Assembly
Attachment Of Spindle Microtubules To Kinetochore
Negative Regulation Of Phosphatase Activity
CENP-A Containing Nucleosome Assembly
Protein Localization To Kinetochore
Cell Division
Spindle Organization
Mitotic Spindle Organization
Chromosome Segregation
Mitotic Spindle Assembly Checkpoint
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Female Meiosis Chromosome Segregation
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Peptidyl-tyrosine Phosphorylation
Meiotic Spindle Assembly Checkpoint
Protein Localization To Kinetochore
Protein Autophosphorylation
Chromosome Separation
Protein Localization To Meiotic Spindle Midzone
Pathways
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Deposition of new CENPA-containing nucleosomes at the centromere
Mitotic Prometaphase
EML4 and NUDC in mitotic spindle formation
Drugs
Pyrazolanthrone
Fostamatinib
BOS172722
Diseases
GWAS
Anxiety and stress-related disorders (
31116379
)
Daytime sleep phenotypes (
27126917
)
Macular thickness (
30535121
)
Interacting Genes
6 interacting genes:
BUB1
BUB1B
DSN1
MIS12
PPP1CA
TTK
14 interacting genes:
APP
AZU1
CDCA8
CDK2
HSP90AA1
KNL1
MAPK6
POLR2A
RAD52
RPS6KA1
TP53
TUBB
TUBB1
USP16
Entrez ID
57082
7272
HPRD ID
10634
04973
Ensembl ID
ENSG00000137812
ENSG00000112742
Uniprot IDs
Q8NG31
P33981
PDB IDs
3SI5
4A1G
4NF9
4NFA
2X9E
2ZMC
2ZMD
3CEK
3DBQ
3GFW
3H9F
3HMN
3HMO
3HMP
3VQU
3W1F
3WYX
3WYY
3WZJ
3WZK
4B94
4BHZ
4BI0
4BI1
4BI2
4C4E
4C4F
4C4G
4C4H
4C4I
4C4J
4CV8
4CV9
4CVA
4D2S
4H7X
4H7Y
4JS8
4JT3
4O6L
4ZEG
5AP0
5AP1
5AP2
5AP3
5AP4
5AP5
5AP6
5AP7
5EH0
5EHL
5EHO
5EHY
5EI2
5EI6
5EI8
5LJJ
5MRB
5N7V
5N84
5N87
5N93
5N9S
5NA0
5NAD
5NTT
5O91
6B4W
6GVJ
6H3K
6N6O
6TN9
6TNB
6TNC
6TND
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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