SHC1 and ERBB3

Data Source:
HPRD (in vivo)

		SHC1	ERBB3
Description		SHC adaptor protein 1	erb-b2 receptor tyrosine kinase 3
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GO Annotations	Cellular Component	Mitochondrial Matrix Cytosol Plasma Membrane Shc-EGFR Complex	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Basal Plasma Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane ERBB3:ERBB2 Complex Receptor Complex
	Molecular Function	Phosphotyrosine Residue Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Neurotrophin TRKA Receptor Binding Protein Binding Phospholipid Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding Ephrin Receptor Binding Epidermal Growth Factor Binding	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Protein Binding ATP Binding Growth Factor Binding Protein Tyrosine Kinase Activator Activity Ubiquitin Protein Ligase Binding Neuregulin Receptor Activity Neuregulin Binding Identical Protein Binding ErbB-3 Class Receptor Binding Protein Heterodimerization Activity
	Biological Process	MAPK Cascade Activation Of MAPK Activity Angiogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Epidermal Growth Factor-activated Receptor Activity Ras Protein Signal Transduction Axon Guidance Heart Development Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Viral Process Cytokine-mediated Signaling Pathway Actin Cytoskeleton Reorganization Interleukin-15-mediated Signaling Pathway IRE1-mediated Unfolded Protein Response Fc-epsilon Receptor Signaling Pathway Interleukin-2-mediated Signaling Pathway ERBB2 Signaling Pathway Regulation Of Growth Defense Response To Bacterium Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Ras Protein Signal Transduction Leukocyte Migration Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Growth Factor Stimulus Cell-cell Adhesion	MAPK Cascade Endocardial Cushion Development Negative Regulation Of Cell Adhesion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Nervous System Development Peripheral Nervous System Development Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Signal Transduction Positive Regulation Of Gene Expression Schwann Cell Differentiation Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Cranial Nerve Development Positive Regulation Of Kinase Activity ERBB2 Signaling Pathway Wound Healing Regulation Of Cell Population Proliferation Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Secretion Neuron Apoptotic Process Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Cardiac Muscle Tissue Development Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Calcineurin-NFAT Signaling Cascade Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Cell Motility
Pathways		Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling SHC1 events in ERBB4 signaling Signalling to RAS Signalling to RAS SHC1 events in EGFR signaling Tie2 Signaling Integrin signaling XBP1(S) activates chaperone genes Interleukin-3, Interleukin-5 and GM-CSF signaling Constitutive Signaling by EGFRvIII RAF/MAP kinase cascade Signal attenuation Insulin receptor signalling cascade Insulin receptor signalling cascade RET signaling Interleukin-15 signaling Interleukin-15 signaling Interleukin-2 signaling Erythropoietin activates RAS Erythropoietin activates RAS Interleukin receptor SHC signaling Constitutive Signaling by Overexpressed ERBB2 Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants
Drugs			Tucatinib
Diseases			Lethal congenital contractural syndrome (LCCS) Type I diabetes mellitus
GWAS		Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Eosinophil counts ( 29403010) Hemoglobin levels ( 32327693) Inflammatory bowel disease ( 27569725) Prostate cancer ( 23535732)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Alopecia areata ( 25608926) Anorexia nervosa ( 28494655) Asthma ( 31959851 30929738 31619474) Asthma (adult onset) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Autoimmune thyroid disease ( 32581359) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 25644384) Household income (MTAG) ( 31844048) Hypothyroidism ( 27182965) Obesity-related traits ( 23251661) Polycystic ovary syndrome ( 26416764) Refractive error ( 32231278) Smoking initiation ( 30617275) Type 1 diabetes ( 21829393 19430480 18198356 17554260 17554300 30572963 18978792) Vitiligo ( 22951725)
Interacting Genes		143 interacting genes: ALK AP2A1 AP2A2 APP AR AXL BCL3 BCR BUB1 C11orf58 CALCOCO2 CALD1 CBL CBLB CBLC CD22 CD247 CD3E CD81 CDH5 CEACAM1 CRK CRKL CSF1R CSF2RB CSF3R CSK DAG1 DDR1 DDR2 DOK1 DUSP23 EGFR EPHA2 EPOR EPS8 ERBB2 ERBB3 ERBB4 ESR1 FAM118B FBXW7 FCGR2A FCGR3A FGFR1 FGFR2 FLT1 FLT4 FYN GAB1 GAB2 GEMIN7 GH1 GHR GRAP GRAP2 GRB2 GRB7 HMOX2 IGF1R IL2 IL2RB IL2RG IL4R IL6ST ILK INPP5D INPPL1 INSR IRS1 IRS2 ITGB3 ITGB4 JAK2 KDR KIT KRT18 LCK LCP2 LRP1 LTK LYN MAP4K1 MAPK1 MAPK14 MAPK6 MAPK8 MAPKAPK2 MET MME MPL MRPL44 MST1R NGFR NPM1 NTRK1 NTRK2 NTRK3 NUDT21 OSGEP PAG1 PAK1 PDGFRB PIK3C2B PIK3R1 PIK3R2 PLCG1 PLCG2 PLPP3 PLSCR1 PPP2R5A PRKCA PRKCD PRKRA PTK2 PTK2B PTPN11 PTPN12 PTPN2 PTPN6 RAPGEF1 RASA1 RB1 RET SH2B2 SHCBP1 SMAD4 SOS1 SOS2 SP1 SRC STAT5A STAT5B SUV39H2 SYK TEC TEK TPR TRIM15 UBASH3B VAV1 VAV3 ZAP70	193 interacting genes: ABL1 ABL2 ACYP1 AGTR2 ALDOA ATP5ME BCAR3 BEND5 BLK BLNK BTK CALM1 CD82 CDC25C CDK5 CFL1 CHN2 CRK CRKL CSPG5 DAB1 DAPP1 DUSP14 DUSP18 DUSP19 DUSP21 DUSP29 EGF EGFR EGR1 ENOPH1 ERBB2 ERBB4 ERG28 EYA4 EZR FAM241B FER FES FGFR1 FGR FHL3 FKBP1A FLNA FLYWCH1 GABARAPL1 GABARAPL2 GRAP2 GRB2 GRB7 HCK HDAC6 HINT1 HSH2D HSPA1A HSPA8 IL6ST ILKAP INPPL1 IRF2BP2 ITK JAK2 JAK3 JUP LAMTOR2 LBHD1 LCK LCP2 LRRC7 LYN MAP1B MATK MTMR1 MTMR10 MTMR2 MTMR6 MTMR8 MTMR9 MUC1 MUC4 MYCBP MYCBP2 NCK1 NCK2 NDUFAB1 NEDD4 NRG1 NRG2 NSMCE1 ODF2L PA2G4 PDGFRA PFDN2 PFDN4 PHPT1 PIK3R1 PIK3R2 PIK3R3 PIN4 PLCG1 PLCG2 PPM1A PPM1B PPM1F PPM1K PPM1M PRDX5 PRKACA PRRG4 PSMA5 PTEN PTGES3 PTK2 PTK2B PTK6 PTPDC1 PTPN11 PTPN12 PTPN20 PTPN6 PTPN7 PTPRH PTPRR RALGAPA1 RASA1 RASA4 RGS4 RIN1 RNF41 RPN1 RTN4 RWDD2A S100A10 SAP18 SELENOK SF3B6 SH2B1 SH2B3 SH2D1A SH2D1B SH2D2A SH2D3A SH2D3C SH3BP2 SHB SHC1 SHC2 SHC3 SHC4 SHD SLA SLA2 SMIM20 SNAP91 SNRPB2 SOCS2 SOCS3 SOCS5 SOCS6 SOS1 SRC SRPK2 STAP1 STYX SYK SYNM TBCA TCEA2 TEC TMA7 TMEM134 TMEM14A TMEM230 TNS1 TNS2 TNS3 TNS4 TPTE TRIR TVP23B TXK TXN TXNL4A VAV1 VAV2 VAV3 VTA1 WRNIP1 YES1 YWHAZ ZAP70 ZNF207 ZNF532
Entrez ID		6464	2065
HPRD ID		02780	01820
Ensembl ID		ENSG00000160691	ENSG00000065361
Uniprot IDs		P29353	P21860
PDB IDs		1MIL 1N3H 1OY2 1QG1 1SHC 1TCE 1WCP 2L1C 4JMH 4XWX 5CZI 6DM4	1M6B 2L9U 3KEX 3LMG 3P11 4LEO 4P59 4RIW 4RIX 4RIY 5CUS 5O4O 5O7P 6KBI 6OP9
Enriched GO Terms of Interacting Partners?
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