PRRG4 and BCL10

Data Source:
BioGRID (two hybrid)

		PRRG4	BCL10
Description		proline rich and Gla domain 4	BCL10 immune signaling adaptor
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Immunological Synapse Polkadots Nucleus Cytoplasm Lysosome Cytosol Cytoplasmic Microtubule CBM Complex Protein-containing Complex Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	Molecular_function Calcium Ion Binding Protein Binding WW Domain Binding	Protease Binding Transcription Coactivator Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding Kinase Activator Activity Enzyme Binding Kinase Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Kinase B Binding Protein Self-association Protein-containing Complex Binding CARD Domain Binding NF-kappaB Binding
	Biological Process	Biological_process	B Cell Apoptotic Process Neural Tube Closure Stimulatory C-type Lectin Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Adaptive Immune Response Negative Regulation Of Mature B Cell Apoptotic Process Cellular Defense Response I-kappaB Kinase/NF-kappaB Signaling Cell Death Response To Fungus Immunoglobulin Mediated Immune Response Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Response To Food Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Lymphotoxin A Production Positive Regulation Of Mast Cell Cytokine Production Positive Regulation Of Kinase Activity Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Innate Immune Response Positive Regulation Of Transcription, DNA-templated T Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity T Cell Apoptotic Process Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells Downstream TCR signaling FCERI mediated NF-kB activation FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Parkinson's disease (age of onset) ( 19772629) Platelet count ( 32888494) Plateletcrit ( 32888494)	Metabolite levels ( 23823483) Multiple sclerosis ( 24076602)
Interacting Genes		9 interacting genes: AOC3 BCL10 ERBB3 ERBB4 HDAC1 HLA-C RBBP8 UBE2K VEGFA	46 interacting genes: AKT1 ANP32B ATM BAAT BIRC3 CARD10 CARD11 CARD14 CARD19 CARD9 CASP9 CCDC180 CDC14B CDK9 CHUK COG6 FBP1 HEMGN IKBKG IL15RA IRAK1 MALT1 MAP3K7 MIB2 NANS NLRC4 OTULIN PELI2 PRRG4 RASA1 RIPK2 RNF181 SLC20A1 SLC9A3R1 SOCS3 SRSF1 TGFB1 TLR4 TNFRSF10A TNFRSF1A TRADD TRAF2 TRMO UBE2N UBE2V2 USHBP1
Entrez ID		79056	8915
HPRD ID		15187	04625
Ensembl ID		ENSG00000135378	ENSG00000142867
Uniprot IDs		A0A0S2Z5N9 Q9BZD6	A0A087WWW9 A2TDT2 O95999
PDB IDs			2MB9 6BZE 6GK2
Enriched GO Terms of Interacting Partners?
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