UBE3A and EIF4G1

Data Source:
BioGRID (two hybrid)

		UBE3A	EIF4G1
Description		ubiquitin protein ligase E3A	eukaryotic translation initiation factor 4 gamma 1
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GO Annotations	Cellular Component	Proteasome Complex Nucleus Cytosol	Nucleus Cytoplasm Cytosol Polysome Cytoplasmic Stress Granule Membrane Eukaryotic Translation Initiation Factor 4F Complex
	Molecular Function	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	RNA Binding MRNA Binding Translation Initiation Factor Activity Protein Binding ATP Binding Translation Factor Activity, RNA Binding Eukaryotic Initiation Factor 4E Binding Translation Initiation Factor Binding Identical Protein Binding Molecular Adaptor Activity
	Biological Process	Ovarian Follicle Development Proteolysis Ubiquitin-dependent Protein Catabolic Process Brain Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Androgen Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Response To Progesterone Sperm Entry Response To Cocaine Response To Hydrogen Peroxide Regulation Of Circadian Rhythm Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Progesterone Receptor Signaling Pathway Protein Autoubiquitination Prostate Gland Growth Negative Regulation Of Dendritic Spine Morphogenesis Protein K48-linked Ubiquitination Positive Regulation Of Golgi Lumen Acidification Cellular Response To Brain-derived Neurotrophic Factor Stimulus Regulation Of Ubiquitin-dependent Protein Catabolic Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Behavioral Fear Response Cap-dependent Translational Initiation Translation Translational Initiation Regulation Of Translational Initiation Negative Regulation Of Autophagy Negative Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Cell Death Viral Process Positive Regulation Of Cell Growth Cellular Response To Nutrient Levels Positive Regulation Of Cellular Protein Metabolic Process Developmental Process Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Macromolecule Biosynthetic Process Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Regulation Of MRNA Stability Positive Regulation Of Neuron Differentiation Regulation Of Gene Silencing By MiRNA Regulation Of Cellular Response To Stress Energy Homeostasis Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Neuron Death Positive Regulation Of Eukaryotic Translation Initiation Factor 4F Complex Assembly Regulation Of Presynapse Assembly Positive Regulation Of MRNA Cap Binding Positive Regulation Of MiRNA Mediated Inhibition Of Translation Regulation Of Polysome Binding
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression mTORC1-mediated signalling Deadenylation of mRNA AUF1 (hnRNP D0) binds and destabilizes mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases		Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
GWAS		Cardiac hypertrophy ( 21348951) Gene methylation in lung tissue ( 25713168) Obesity-related traits ( 23251661)	Menarche (age at onset) ( 25231870) Red blood cell count ( 32888494)
Interacting Genes		125 interacting genes: ACTA2 ACTB ACTBL2 ACTR3 ADRM1 AFG3L1P AFTPH AHSP ANXA1 APP AR ARC ARHGDIB ASAP3 ATG9A BARD1 BLK BPY2 BPY2B BPY2C BRCA1 C11orf49 CALR CDK1 CDK4 CDKN1B CEBPZ CGGBP1 CTNNB1 DAZAP2 DLG1 E2F1 EAPP EID1 EIF4G1 FAF2 GFAP GTF3C1 HBA1 HPCAL4 HSP90AB1 HSPA4 HSPA5 JADE1 KLHL38 KRT1 KRT5 KRT7 KRT9 LCK MAGEA12 MAGEA8 MAPK1 MARF1 MCM6 MCM7 MDM1 MDM2 MEOX2 NBPF14 NDUFA13 NELFCD NOMO2 NR4A3 PARVA PAX5 PAX6 PDE1B PDIA3 PDIA6 PGR PML POLE4 PRAG1 PRDX1 PRKACA PRMT5 PSAP PTCD3 RAD23A RAD23B RARA RMI1 RPS15A RYBP SACS SCAMP1 SCRIB SHBG SIRT6 SMAD9 SNAPC3 SOD1 SPINK1 SUMO3 TALDO1 TAT TBC1D14 TCF19 TMEM14B TP53 TP53BP2 TRIM65 TSC2 TTC23L TTC3 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2G1 UBE2G2 UBE2L3 UBE2L6 UBE2N UBQLN1 UBQLN2 WBP2 YOD1 YWHAE YWHAG YWHAZ ZNF250 ZNF446	40 interacting genes: A1CF ANXA5 ATPAF2 CCDC57 CDKN2D CENPU CIB1 CTBP2 DTX2 EIF1 EIF3A EIF3B EIF3I EIF4A1 EIF4A2 EIF4E EIF5 ENKD1 FXR2 GK HSPB1 HTRA2 KRT31 KRT34 MKNK1 MKNK2 NCBP1 NCBP2 NTAQ1 PABPC1 PAK2 PDCD4 PEF1 SMARCD1 SRPK2 SUMO2 TRAF2 UBE3A UPF2 ZFYVE9
Entrez ID		7337	1981
HPRD ID		03375	06774
Ensembl ID		ENSG00000114062	ENSG00000114867
Uniprot IDs		Q05086 Q9H2G0	B2RU06 B2RU10 B4DSI9 O95065 Q04637 Q96I65
PDB IDs		1C4Z 1D5F 1EQX 2KR1 4GIZ 4XR8 6SJV 6SLM 6TGK 6U19	1LJ2 1UG3 2W97 4AZA 4F02 5EHC 5EI3 5EIR 5T46 6ZMW
Enriched GO Terms of Interacting Partners?
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