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UBE3A and TMEM14B
Data Source:
BioGRID
(two hybrid)
UBE3A
TMEM14B
Description
ubiquitin protein ligase E3A
transmembrane protein 14B
Image
No pdb structure
GO Annotations
Cellular Component
Proteasome Complex
Nucleus
Cytosol
Mitochondrial Inner Membrane
Integral Component Of Membrane
Mitochondrial Membrane
Molecular Function
Transcription Coactivator Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Protein Binding
Identical Protein Binding
Biological Process
Ovarian Follicle Development
Proteolysis
Ubiquitin-dependent Protein Catabolic Process
Brain Development
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Viral Process
Androgen Receptor Signaling Pathway
Positive Regulation Of Protein Ubiquitination
Response To Progesterone
Sperm Entry
Response To Cocaine
Response To Hydrogen Peroxide
Regulation Of Circadian Rhythm
Positive Regulation Of Transcription By RNA Polymerase II
Rhythmic Process
Progesterone Receptor Signaling Pathway
Protein Autoubiquitination
Prostate Gland Growth
Negative Regulation Of Dendritic Spine Morphogenesis
Protein K48-linked Ubiquitination
Positive Regulation Of Golgi Lumen Acidification
Cellular Response To Brain-derived Neurotrophic Factor Stimulus
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Mitochondrial Transport
Cerebral Cortex Development
Neural Precursor Cell Proliferation
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
GWAS
Cardiac hypertrophy (
21348951
)
Gene methylation in lung tissue (
25713168
)
Obesity-related traits (
23251661
)
Response to (pegylated) interferon in HBeAg-negative hepatitis B (
30715261
)
Interacting Genes
125 interacting genes:
ACTA2
ACTB
ACTBL2
ACTR3
ADRM1
AFG3L1P
AFTPH
AHSP
ANXA1
APP
AR
ARC
ARHGDIB
ASAP3
ATG9A
BARD1
BLK
BPY2
BPY2B
BPY2C
BRCA1
C11orf49
CALR
CDK1
CDK4
CDKN1B
CEBPZ
CGGBP1
CTNNB1
DAZAP2
DLG1
E2F1
EAPP
EID1
EIF4G1
FAF2
GFAP
GTF3C1
HBA1
HPCAL4
HSP90AB1
HSPA4
HSPA5
JADE1
KLHL38
KRT1
KRT5
KRT7
KRT9
LCK
MAGEA12
MAGEA8
MAPK1
MARF1
MCM6
MCM7
MDM1
MDM2
MEOX2
NBPF14
NDUFA13
NELFCD
NOMO2
NR4A3
PARVA
PAX5
PAX6
PDE1B
PDIA3
PDIA6
PGR
PML
POLE4
PRAG1
PRDX1
PRKACA
PRMT5
PSAP
PTCD3
RAD23A
RAD23B
RARA
RMI1
RPS15A
RYBP
SACS
SCAMP1
SCRIB
SHBG
SIRT6
SMAD9
SNAPC3
SOD1
SPINK1
SUMO3
TALDO1
TAT
TBC1D14
TCF19
TMEM14B
TP53
TP53BP2
TRIM65
TSC2
TTC23L
TTC3
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2G1
UBE2G2
UBE2L3
UBE2L6
UBE2N
UBQLN1
UBQLN2
WBP2
YOD1
YWHAE
YWHAG
YWHAZ
ZNF250
ZNF446
229 interacting genes:
ABHD16A
ABHD5
ACSL5
ADAM33
AGPAT3
AGPAT4
AGR3
AGTRAP
APOC2
APOC4
ARL6IP1
ARL8B
ARV1
ATP13A1
B4GALT7
BIK
BLCAP
BMP10
BTN2A2
C10orf67
C14orf180
C1GALT1
C2CD2L
CCL4
CD79A
CEPT1
CFHR5
CIDEB
CLDN10
CLDND2
CMTM5
CMTM8
CNIH2
CNIH3
CNIH4
COMT
CPLX4
CREB3
CREB3L1
CXCL16
CYB561
CYB5R3
DEFB103A
DEFB103B
DGAT2L6
DHRSX
EBP
EI24
EMC6
EPHX4
ERGIC3
EXTL1
FA2H
FADS6
FAM209A
FCER1G
FHL3
FIS1
FKBP8
FXYD6-FXYD2
GDAP1
GIMAP1
GPR152
GPX8
GYPA
GYPC
HEXB
HIBADH
HIGD1C
HMOX1
HMOX2
HSD17B11
HSD3B1
IER3IP1
IFITM3
INSIG2
ITGAM
JAGN1
KCNA1
KCNK1
KHDRBS2
LEPROTL1
LMNA
LPAR3
LRCH1
MAL2
MARCHF5
MEOX2
MFSD12
MFSD5
MGAM
MID2
MMD2
MS4A13
MS4A4A
NAT8
NCALD
NDUFA3
NEU1
NINJ1
NINJ2
NIPAL3
ORMDL1
OTULINL
PAGE1
PDPN
PDZK1IP1
PEX11G
PIGF
PLLP
PLP1
PLP2
PMP22
PNLIPRP1
PPP2R3B
PRAF2
PRH1
PRTFDC1
PSMD3
PTPMT1
RABAC1
RHD
RHOT2
SAR1B
SCAMP5
SCN3B
SCRG1
SERF1A
SERF1B
SERP1
SERP2
SFT2D1
SFT2D2
SFXN1
SFXN2
SFXN3
SLC16A10
SLC16A13
SLC18A1
SLC19A3
SLC2A6
SLC30A3
SLC30A8
SLC35A4
SLC35C2
SLC35E3
SLC35E4
SLC35F1
SLC35F6
SLC35G1
SLC39A2
SLC39A7
SLC48A1
SLC7A8
SMAGP
SMPD2
SPRY2
SQLE
ST6GAL2
STOM
STX12
STX3
STX6
STX8
SUCNR1
SYNGR1
SYNJ2BP
TAP1
TAS2R19
TBC1D20
TEX44
THBD
TIMM22
TIMM23
TIMMDC1
TLCD1
TM4SF4
TMEM11
TMEM120A
TMEM120B
TMEM121
TMEM147
TMEM14A
TMEM14C
TMEM187
TMEM19
TMEM199
TMEM203
TMEM220
TMEM222
TMEM229B
TMEM243
TMEM254
TMEM255B
TMEM267
TMEM42
TMEM50A
TMEM50B
TMEM51
TMEM60
TMEM69
TMEM97
TMIE
TMUB1
TMX2
TOMM6
TSPAN2
TSPO
TVP23B
UBE2J1
UBE2J2
UBE3A
UBIAD1
UBXN8
UNC50
UNC93A
VAMP1
VAMP5
VRK2
VTI1B
YIF1A
YIPF1
YIPF2
YIPF4
YIPF6
ZDHHC11
ZDHHC22
ZDHHC24
ZFPL1
Entrez ID
7337
81853
HPRD ID
03375
15523
Ensembl ID
ENSG00000114062
ENSG00000137210
Uniprot IDs
Q05086
Q9H2G0
A0A024QZV7
A0A087WU83
C9JCY4
C9JQS0
Q9NUH8
PDB IDs
1C4Z
1D5F
1EQX
2KR1
4GIZ
4XR8
6SJV
6SLM
6TGK
6U19
Enriched GO Terms of Interacting Partners
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