UBE3A and PTCD3

Data Source:
BioGRID (two hybrid)

		UBE3A	PTCD3
Description		ubiquitin protein ligase E3A	pentatricopeptide repeat domain 3
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GO Annotations	Cellular Component	Proteasome Complex Nucleus Cytosol	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Cytosol Ribosome Plasma Membrane
	Molecular Function	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	RNA Binding Protein Binding RRNA Binding Ribosomal Small Subunit Binding
	Biological Process	Ovarian Follicle Development Proteolysis Ubiquitin-dependent Protein Catabolic Process Brain Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Androgen Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Response To Progesterone Sperm Entry Response To Cocaine Response To Hydrogen Peroxide Regulation Of Circadian Rhythm Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Progesterone Receptor Signaling Pathway Protein Autoubiquitination Prostate Gland Growth Negative Regulation Of Dendritic Spine Morphogenesis Protein K48-linked Ubiquitination Positive Regulation Of Golgi Lumen Acidification Cellular Response To Brain-derived Neurotrophic Factor Stimulus Regulation Of Ubiquitin-dependent Protein Catabolic Process	Regulation Of Translation Mitochondrial Translation Mitochondrial Translational Elongation Mitochondrial Translational Termination
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination
Drugs
Diseases		Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
GWAS		Cardiac hypertrophy ( 21348951) Gene methylation in lung tissue ( 25713168) Obesity-related traits ( 23251661)	Diastolic blood pressure ( 27841878) Facial emotion recognition (sad faces) ( 28608620) Pulse pressure ( 27841878) Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) ( 21130132) Systolic blood pressure ( 27841878)
Interacting Genes		125 interacting genes: ACTA2 ACTB ACTBL2 ACTR3 ADRM1 AFG3L1P AFTPH AHSP ANXA1 APP AR ARC ARHGDIB ASAP3 ATG9A BARD1 BLK BPY2 BPY2B BPY2C BRCA1 C11orf49 CALR CDK1 CDK4 CDKN1B CEBPZ CGGBP1 CTNNB1 DAZAP2 DLG1 E2F1 EAPP EID1 EIF4G1 FAF2 GFAP GTF3C1 HBA1 HPCAL4 HSP90AB1 HSPA4 HSPA5 JADE1 KLHL38 KRT1 KRT5 KRT7 KRT9 LCK MAGEA12 MAGEA8 MAPK1 MARF1 MCM6 MCM7 MDM1 MDM2 MEOX2 NBPF14 NDUFA13 NELFCD NOMO2 NR4A3 PARVA PAX5 PAX6 PDE1B PDIA3 PDIA6 PGR PML POLE4 PRAG1 PRDX1 PRKACA PRMT5 PSAP PTCD3 RAD23A RAD23B RARA RMI1 RPS15A RYBP SACS SCAMP1 SCRIB SHBG SIRT6 SMAD9 SNAPC3 SOD1 SPINK1 SUMO3 TALDO1 TAT TBC1D14 TCF19 TMEM14B TP53 TP53BP2 TRIM65 TSC2 TTC23L TTC3 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2G1 UBE2G2 UBE2L3 UBE2L6 UBE2N UBQLN1 UBQLN2 WBP2 YOD1 YWHAE YWHAG YWHAZ ZNF250 ZNF446	22 interacting genes: ATF4 BIRC7 HGS IFITM2 LNX2 LUC7L2 MIR128-2 MIR18B MIR200B MIR200C MIR205 MIR21 MIR214 MIR34B MIR34C MIR363 MIRLET7A2 MIRLET7F2 MIRLET7G MT-RNR1 TBPL1 UBE3A
Entrez ID		7337	55037
HPRD ID		03375	08631
Ensembl ID		ENSG00000114062	ENSG00000132300
Uniprot IDs		Q05086 Q9H2G0	Q96EY7
PDB IDs		1C4Z 1D5F 1EQX 2KR1 4GIZ 4XR8 6SJV 6SLM 6TGK 6U19	3J9M 6NU2 6NU3 6RW4 6RW5 6VLZ 6VMI 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG
Enriched GO Terms of Interacting Partners?
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