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UBE3A and TSC2
Data Source:
BioGRID
(pull down)
UBE3A
TSC2
Description
ubiquitin protein ligase E3A
TSC complex subunit 2
Image
No pdb structure
GO Annotations
Cellular Component
Proteasome Complex
Nucleus
Cytosol
Nucleus
Cytoplasm
Lysosome
Golgi Apparatus
Cytosol
Postsynaptic Density
Membrane
TSC1-TSC2 Complex
Perinuclear Region Of Cytoplasm
Molecular Function
Transcription Coactivator Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
GTPase Activator Activity
Protein Binding
Phosphatase Binding
Small GTPase Binding
Protein Homodimerization Activity
Hsp90 Protein Binding
Biological Process
Ovarian Follicle Development
Proteolysis
Ubiquitin-dependent Protein Catabolic Process
Brain Development
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Viral Process
Androgen Receptor Signaling Pathway
Positive Regulation Of Protein Ubiquitination
Response To Progesterone
Sperm Entry
Response To Cocaine
Response To Hydrogen Peroxide
Regulation Of Circadian Rhythm
Positive Regulation Of Transcription By RNA Polymerase II
Rhythmic Process
Progesterone Receptor Signaling Pathway
Protein Autoubiquitination
Prostate Gland Growth
Negative Regulation Of Dendritic Spine Morphogenesis
Protein K48-linked Ubiquitination
Positive Regulation Of Golgi Lumen Acidification
Cellular Response To Brain-derived Neurotrophic Factor Stimulus
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Neural Tube Closure
Negative Regulation Of Protein Kinase Activity
Protein Import Into Nucleus
Endocytosis
Heart Development
Protein Localization
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Phosphatidylinositol 3-kinase Signaling
Viral Process
Vesicle-mediated Transport
Positive Regulation Of Macroautophagy
Regulation Of Endocytosis
Negative Regulation Of Wnt Signaling Pathway
Negative Regulation Of TOR Signaling
Anoikis
Protein Kinase B Signaling
Positive Regulation Of GTPase Activity
Regulation Of Insulin Receptor Signaling Pathway
Negative Regulation Of Insulin Receptor Signaling Pathway
Insulin-like Growth Factor Receptor Signaling Pathway
Positive Chemotaxis
Regulation Of Small GTPase Mediated Signal Transduction
Regulation Of Cell Cycle
Negative Regulation Of Protein Kinase B Signaling
Negative Regulation Of Mitophagy
Pathways
Antigen processing: Ubiquitination & Proteasome degradation
Macroautophagy
Inhibition of TSC complex formation by PKB
AKT phosphorylates targets in the cytosol
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Constitutive Signaling by AKT1 E17K in Cancer
TBC/RABGAPs
Drugs
Diseases
Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
Lymphangioleiomyomatosis (LAM)
Tuberous sclerosis complex (TSC); Bourneville-Pringle disease
GWAS
Cardiac hypertrophy (
21348951
)
Gene methylation in lung tissue (
25713168
)
Obesity-related traits (
23251661
)
Major depressive disorder (
29317602
)
Obesity-related traits (
23251661
)
White blood cell count (
32888494
)
Interacting Genes
125 interacting genes:
ACTA2
ACTB
ACTBL2
ACTR3
ADRM1
AFG3L1P
AFTPH
AHSP
ANXA1
APP
AR
ARC
ARHGDIB
ASAP3
ATG9A
BARD1
BLK
BPY2
BPY2B
BPY2C
BRCA1
C11orf49
CALR
CDK1
CDK4
CDKN1B
CEBPZ
CGGBP1
CTNNB1
DAZAP2
DLG1
E2F1
EAPP
EID1
EIF4G1
FAF2
GFAP
GTF3C1
HBA1
HPCAL4
HSP90AB1
HSPA4
HSPA5
JADE1
KLHL38
KRT1
KRT5
KRT7
KRT9
LCK
MAGEA12
MAGEA8
MAPK1
MARF1
MCM6
MCM7
MDM1
MDM2
MEOX2
NBPF14
NDUFA13
NELFCD
NOMO2
NR4A3
PARVA
PAX5
PAX6
PDE1B
PDIA3
PDIA6
PGR
PML
POLE4
PRAG1
PRDX1
PRKACA
PRMT5
PSAP
PTCD3
RAD23A
RAD23B
RARA
RMI1
RPS15A
RYBP
SACS
SCAMP1
SCRIB
SHBG
SIRT6
SMAD9
SNAPC3
SOD1
SPINK1
SUMO3
TALDO1
TAT
TBC1D14
TCF19
TMEM14B
TP53
TP53BP2
TRIM65
TSC2
TTC23L
TTC3
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2G1
UBE2G2
UBE2L3
UBE2L6
UBE2N
UBQLN1
UBQLN2
WBP2
YOD1
YWHAE
YWHAG
YWHAZ
ZNF250
ZNF446
44 interacting genes:
AKT1
AKT2
AKT3
CALM1
CBY2
CCND1
CDKN1B
ESR1
FBXL6
FBXW5
GRB2
GSK3B
LNX1
MAPK1
MAPK3
MAPKAPK2
MDFI
NEK1
PAM
PIN1
PLK2
PPP2CA
PRKAA1
PTK2
PTPN11
RAB5A
RABEP1
RHEB
RPS6KA1
SFN
SMAD2
SMAD3
SUPT6H
TK1
TRIM55
TRIM63
TSC1
UBE3A
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
Entrez ID
7337
7249
HPRD ID
03375
01850
Ensembl ID
ENSG00000114062
ENSG00000103197
Uniprot IDs
Q05086
Q9H2G0
B3KWH7
H3BMQ0
P49815
Q5HYF7
X5D7Q2
PDB IDs
1C4Z
1D5F
1EQX
2KR1
4GIZ
4XR8
6SJV
6SLM
6TGK
6U19
Enriched GO Terms of Interacting Partners
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