UBE2B and UBR1

Data Source:
BioGRID (affinity chromatography technology, two hybrid)
HPRD (two hybrid)

		UBE2B	UBR1
Description		ubiquitin conjugating enzyme E2 B	ubiquitin protein ligase E3 component n-recognin 1
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GO Annotations	Cellular Component	Chromatin XY Body Nucleus Nucleoplasm Replication Fork Cytoplasm Plasma Membrane HULC Complex	Ubiquitin Ligase Complex Proteasome Complex Cytoplasm Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity Leucine Binding
	Biological Process	Protein Polyubiquitination In Utero Embryonic Development DNA Repair Postreplication Repair Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Spermatogenesis Sperm Axoneme Assembly Response To UV Positive Regulation Of Reciprocal Meiotic Recombination Protein Ubiquitination Histone Ubiquitination Negative Regulation Of Histone Phosphorylation Histone H2A Ubiquitination Response To Drug DNA Damage Response, Detection Of DNA Damage Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of CAMP-mediated Signaling Meiotic Telomere Clustering Protein Stabilization Chiasma Assembly Protein Autoubiquitination Histone Lysine Demethylation Synaptonemal Complex Organization Protein K63-linked Ubiquitination Heterochromatin Maintenance Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of Canonical Wnt Signaling Pathway	Protein Ubiquitination Negative Regulation Of TOR Signaling Cellular Response To Leucine Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway
Pathways		Recognition of DNA damage by PCNA-containing replication complex Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases			Johanson-Blizzard syndrome
GWAS		Relative amplitude of rest-activity cycles ( 30120083)	MGMT methylation in smokers ( 26183928) Triglycerides ( 25961943)
Interacting Genes		25 interacting genes: BIRC2 CBX5 CDKN1B CNOT4 CRMP1 CTNNB1 H2AC20 HERPUD2 MED31 PCNA PRKN RAD18 RC3H1 RC3H2 RNF20 RNF4 RNF40 TRIM14 TRIM45 UBA1 UBR1 UBR2 UBR3 UBR5 UNC119	28 interacting genes: ANXA3 ARL15 ARL3 ARL4D BCL2L1 BTBD2 CDC42 CDC6 DLEU1 DNAJB11 FOS FTH1 GADD45A GSK3B LAMA4 LAMTOR3 NDUFA4L2 NTAN1 NTAQ1 NUDT3 PTPRS SERPINB9 SPRY2 TAC3 TP53I3 UBE2A UBE2B UBE2D2
Entrez ID		7320	197131
HPRD ID		01533	09342
Ensembl ID		ENSG00000119048	ENSG00000159459
Uniprot IDs		P63146	Q8IWV7
PDB IDs		1JAS 1NXA 2Y4W 2YB6 2YBF	3NY1 5TDC
Enriched GO Terms of Interacting Partners?
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