UBR1 and BTBD2

Data Source:
HPRD (two hybrid)

		UBR1	BTBD2
Description		ubiquitin protein ligase E3 component n-recognin 1	BTB domain containing 2
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Proteasome Complex Cytoplasm Cytosol	P-body Cytosol
	Molecular Function	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity Leucine Binding	Protein Binding
	Biological Process	Protein Ubiquitination Negative Regulation Of TOR Signaling Cellular Response To Leucine Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway	Neurogenesis
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Johanson-Blizzard syndrome
GWAS		MGMT methylation in smokers ( 26183928) Triglycerides ( 25961943)	Mitochondrial DNA copy number (white blood cells) ( 30704525) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 32888494)
Interacting Genes		28 interacting genes: ANXA3 ARL15 ARL3 ARL4D BCL2L1 BTBD2 CDC42 CDC6 DLEU1 DNAJB11 FOS FTH1 GADD45A GSK3B LAMA4 LAMTOR3 NDUFA4L2 NTAN1 NTAQ1 NUDT3 PTPRS SERPINB9 SPRY2 TAC3 TP53I3 UBE2A UBE2B UBE2D2	35 interacting genes: BRD7 CCDC90B CCNC CDK2 CINP COPS6 CRMP1 CUL3 DPPA4 EEF1A1 ERG28 GAPDH GBP2 GDF9 IGSF21 KPNA2 MLH1 NGB NTAQ1 OSGIN1 PSMD5 PTN RBM48 SETDB1 SMAD1 SMAD2 TDP2 TGFBR1 TLE1 TOP1 TP53 TRIM5 UBR1 UNC119 ZNF512B
Entrez ID		197131	55643
HPRD ID		09342	12252
Ensembl ID		ENSG00000159459	ENSG00000133243
Uniprot IDs		Q8IWV7	Q9BX70
PDB IDs		3NY1 5TDC	3NO8
Enriched GO Terms of Interacting Partners?
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