UBR1 and UBE2A

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		UBR1	UBE2A
Description		ubiquitin protein ligase E3 component n-recognin 1	ubiquitin conjugating enzyme E2 A
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Proteasome Complex Cytoplasm Cytosol	Chromatin XY Body Nucleoplasm Cytosol HULC Complex
	Molecular Function	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity Leucine Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Ubiquitination Negative Regulation Of TOR Signaling Cellular Response To Leucine Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway	Protein Polyubiquitination Blastocyst Hatching DNA Repair Postreplication Repair Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell Population Proliferation Response To UV Protein Ubiquitination Histone Ubiquitination Histone H2A Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Maternal Process Involved In Female Pregnancy Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Johanson-Blizzard syndrome
GWAS		MGMT methylation in smokers ( 26183928) Triglycerides ( 25961943)	Brain connectivity ( 23471985)
Interacting Genes		28 interacting genes: ANXA3 ARL15 ARL3 ARL4D BCL2L1 BTBD2 CDC42 CDC6 DLEU1 DNAJB11 FOS FTH1 GADD45A GSK3B LAMA4 LAMTOR3 NDUFA4L2 NTAN1 NTAQ1 NUDT3 PTPRS SERPINB9 SPRY2 TAC3 TP53I3 UBE2A UBE2B UBE2D2	26 interacting genes: CBX5 CDK1 CDK2 CDK9 CDKN2A CRMP1 EEF1D H2BC21 HLTF KCMF1 MDM2 PCNA PRKN RAD18 RC3H1 RNF20 RNF4 RNF40 SDCBP TP53 TRIM27 UBA1 UBR1 UBR3 UBR5 ZMYM2
Entrez ID		197131	7319
HPRD ID		09342	02422
Ensembl ID		ENSG00000159459	ENSG00000077721
Uniprot IDs		Q8IWV7	A0A0D9SG71 P49459
PDB IDs		3NY1 5TDC	6CYO 6CYR
Enriched GO Terms of Interacting Partners?
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