UBR1 and DNAJB11

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		UBR1	DNAJB11
Description		ubiquitin protein ligase E3 component n-recognin 1	DnaJ heat shock protein family (Hsp40) member B11
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Proteasome Complex Cytoplasm Cytosol	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Membrane Chaperone Complex
	Molecular Function	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity Leucine Binding	Protein Binding Unfolded Protein Binding Misfolded Protein Binding
	Biological Process	Protein Ubiquitination Negative Regulation Of TOR Signaling Cellular Response To Leucine Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway	Protein Folding Positive Regulation Of ATPase Activity IRE1-mediated Unfolded Protein Response Protein Maturation
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	XBP1(S) activates chaperone genes
Drugs
Diseases		Johanson-Blizzard syndrome
GWAS		MGMT methylation in smokers ( 26183928) Triglycerides ( 25961943)
Interacting Genes		28 interacting genes: ANXA3 ARL15 ARL3 ARL4D BCL2L1 BTBD2 CDC42 CDC6 DLEU1 DNAJB11 FOS FTH1 GADD45A GSK3B LAMA4 LAMTOR3 NDUFA4L2 NTAN1 NTAQ1 NUDT3 PTPRS SERPINB9 SPRY2 TAC3 TP53I3 UBE2A UBE2B UBE2D2	24 interacting genes: ANKZF1 APOBEC1 BAG6 CEP70 COL6A1 CRMP1 DDAH2 DNAJC13 DRAP1 EIF3D EZH2 FAF1 GRB2 HSPA1A HTN3 PAXIP1 PTN SIMC1 SNX5 SPRED1 SUMO4 UBQLN4 UBR1 ZZZ3
Entrez ID		197131	51726
HPRD ID		09342	07485
Ensembl ID		ENSG00000159459	ENSG00000090520
Uniprot IDs		Q8IWV7	Q9UBS4
PDB IDs		3NY1 5TDC
Enriched GO Terms of Interacting Partners?
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