UBE2B and MED31

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		UBE2B	MED31
Description		ubiquitin conjugating enzyme E2 B	mediator complex subunit 31
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin XY Body Nucleus Nucleoplasm Replication Fork Cytoplasm Plasma Membrane HULC Complex	Ubiquitin Ligase Complex Nucleoplasm Mediator Complex Core Mediator Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity	Transcription Coregulator Activity Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination In Utero Embryonic Development DNA Repair Postreplication Repair Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Spermatogenesis Sperm Axoneme Assembly Response To UV Positive Regulation Of Reciprocal Meiotic Recombination Protein Ubiquitination Histone Ubiquitination Negative Regulation Of Histone Phosphorylation Histone H2A Ubiquitination Response To Drug DNA Damage Response, Detection Of DNA Damage Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of CAMP-mediated Signaling Meiotic Telomere Clustering Protein Stabilization Chiasma Assembly Protein Autoubiquitination Histone Lysine Demethylation Synaptonemal Complex Organization Protein K63-linked Ubiquitination Heterochromatin Maintenance Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of Canonical Wnt Signaling Pathway	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Protein Ubiquitination Negative Regulation Of Fibroblast Proliferation Limb Development
Pathways		Recognition of DNA damage by PCNA-containing replication complex Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS		Relative amplitude of rest-activity cycles ( 30120083)	LDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883)
Interacting Genes		25 interacting genes: BIRC2 CBX5 CDKN1B CNOT4 CRMP1 CTNNB1 H2AC20 HERPUD2 MED31 PCNA PRKN RAD18 RC3H1 RC3H2 RNF20 RNF4 RNF40 TRIM14 TRIM45 UBA1 UBR1 UBR2 UBR3 UBR5 UNC119	59 interacting genes: AGR2 ANXA7 ASCC2 CACNB4 CCT7 CDKN1A CPE DAZAP2 DLEU1 DNM1 EEF1G EGR2 EPN1 ERH FAM118B GADD45G GSTM4 HGH1 HMOX2 HNRNPUL1 HSPB1 HSPB3 HTT LAMA4 LYPLA2 MAFG MED18 MED19 MED7 MED8 MED9 MOB4 NAF1 NFATC2 NR4A1 ORAI2 PABPC4 PAFAH1B3 PFDN1 PMF1 PQBP1 PRMT1 PSMD11 RAB25 RBM23 RFC5 RPA2 SAT1 SELENBP1 SERPINB9 SMN1 TGIF1 TINAGL1 TK1 TLE5 UBE2B WDCP ZBTB45 ZSCAN1
Entrez ID		7320	51003
HPRD ID		01533	14382
Ensembl ID		ENSG00000119048	ENSG00000108590
Uniprot IDs		P63146	Q9Y3C7
PDB IDs		1JAS 1NXA 2Y4W 2YB6 2YBF
Enriched GO Terms of Interacting Partners?
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