UBR1 and TAC3

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		UBR1	TAC3
Description		ubiquitin protein ligase E3 component n-recognin 1	tachykinin precursor 3
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Proteasome Complex Cytoplasm Cytosol	Extracellular Region Extracellular Space
	Molecular Function	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity Leucine Binding	Signaling Receptor Binding Protein Binding
	Biological Process	Protein Ubiquitination Negative Regulation Of TOR Signaling Cellular Response To Leucine Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway	G Protein-coupled Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Neuropeptide Signaling Pathway Female Pregnancy Positive Regulation Of Blood Pressure
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Tachykinin receptors bind tachykinins G alpha (q) signalling events
Drugs			Copper
Diseases		Johanson-Blizzard syndrome	Hypogonadotropic hypogonadism; Kallmann syndrome (KAL)
GWAS		MGMT methylation in smokers ( 26183928) Triglycerides ( 25961943)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31959851 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Menopause (age at onset) ( 26414677) Red cell distribution width ( 28957414) Schizophrenia ( 25056061)
Interacting Genes		28 interacting genes: ANXA3 ARL15 ARL3 ARL4D BCL2L1 BTBD2 CDC42 CDC6 DLEU1 DNAJB11 FOS FTH1 GADD45A GSK3B LAMA4 LAMTOR3 NDUFA4L2 NTAN1 NTAQ1 NUDT3 PTPRS SERPINB9 SPRY2 TAC3 TP53I3 UBE2A UBE2B UBE2D2	12 interacting genes: CCDC90B ELP1 FEZ1 GPRASP1 PRB1 PRH1 PTN TACR1 TACR2 TACR3 UBC UBR1
Entrez ID		197131	6866
HPRD ID		09342	08877
Ensembl ID		ENSG00000159459	ENSG00000166863
Uniprot IDs		Q8IWV7	A0A024RB47 A0A024RB97 Q9UHF0
PDB IDs		3NY1 5TDC	1P9F
Enriched GO Terms of Interacting Partners?
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