UBR1 and LAMA4

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		UBR1	LAMA4
Description		ubiquitin protein ligase E3 component n-recognin 1	laminin subunit alpha 4
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Proteasome Complex Cytoplasm Cytosol	Extracellular Region Basement Membrane Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity Leucine Binding	Signaling Receptor Binding Extracellular Matrix Structural Constituent Protein Binding
	Biological Process	Protein Ubiquitination Negative Regulation Of TOR Signaling Cellular Response To Leucine Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway	Cell Adhesion Regulation Of Cell Adhesion Extracellular Matrix Organization Regulation Of Cell Migration Regulation Of Embryonic Development Negative Regulation Of Cold-induced Thermogenesis
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans MET activates PTK2 signaling
Drugs
Diseases		Johanson-Blizzard syndrome
GWAS		MGMT methylation in smokers ( 26183928) Triglycerides ( 25961943)	Bipolar disorder ( 31043756) Metabolite levels ( 23823483)
Interacting Genes		28 interacting genes: ANXA3 ARL15 ARL3 ARL4D BCL2L1 BTBD2 CDC42 CDC6 DLEU1 DNAJB11 FOS FTH1 GADD45A GSK3B LAMA4 LAMTOR3 NDUFA4L2 NTAN1 NTAQ1 NUDT3 PTPRS SERPINB9 SPRY2 TAC3 TP53I3 UBE2A UBE2B UBE2D2	17 interacting genes: APC ATF7IP BRD7 COPS6 EEF1A1 FHL1 GAPDH LRIF1 MED31 PTN RTN4 RTP2 TP53 TUBB2A UBR1 UNC119 ZHX1
Entrez ID		197131	3910
HPRD ID		09342	02532
Ensembl ID		ENSG00000159459	ENSG00000112769
Uniprot IDs		Q8IWV7	A0A0A0MQS9 A0A0A0MTC7 Q16363 Q5D044
PDB IDs		3NY1 5TDC
Enriched GO Terms of Interacting Partners?
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