TXNRD1 and TXNDC17

Data Source:
HPRD (in vitro)

		TXNRD1	TXNDC17
Description		thioredoxin reductase 1	thioredoxin domain containing 17
Image
GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Cytoplasm Mitochondrion Cytosol Extracellular Exosome	Cytosol Extracellular Exosome
	Molecular Function	Thioredoxin-disulfide Reductase Activity Protein Binding Protein Disulfide Oxidoreductase Activity Flavin Adenine Dinucleotide Binding	Peroxidase Activity Protein Binding Protein-disulfide Reductase Activity
	Biological Process	Mesoderm Formation Selenium Compound Metabolic Process Signal Transduction Cell Population Proliferation Nucleobase-containing Small Molecule Interconversion Regulation Of Lipid Metabolic Process Cellular Response To Oxidative Stress Cell Redox Homeostasis Cellular Oxidant Detoxification	Tumor Necrosis Factor-mediated Signaling Pathway Cellular Oxidant Detoxification
Pathways		PPARA activates gene expression Metabolism of ingested H2SeO4 and H2SeO3 into H2Se Detoxification of Reactive Oxygen Species Interconversion of nucleotide di- and triphosphates Metabolism of ingested MeSeO2H into MeSeH Uptake and function of diphtheria toxin TP53 Regulates Metabolic Genes
Drugs		Arsenic trioxide NADPH Flavin adenine dinucleotide Spermidine Fotemustine Motexafin gadolinium PX-12
Diseases
GWAS		Blood protein levels ( 30072576) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Logical memory (delayed recall) in normal cognition ( 29274321) Toenail selenium levels ( 25343990)	LDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883)
Interacting Genes		11 interacting genes: DMRTC2 ESR1 ESR2 GLRX2 LINC01554 POU2F1 POU2F2 PPP1R16A THRA TXNDC17 TXNIP	9 interacting genes: AVP DYNLL1 EXOSC8 INCA1 INS OXT RUFY1 TINF2 TXNRD1
Entrez ID		7296	84817
HPRD ID		03068	11656
Ensembl ID		ENSG00000198431	ENSG00000129235
Uniprot IDs		B7Z2S5 Q16881	A0A140VJY7 Q9BRA2
PDB IDs		1W1C 2CFY 2J3N 2ZZ0 2ZZB 2ZZC 3QFA 3QFB	1WOU
Enriched GO Terms of Interacting Partners?
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