TXNRD1 and GLRX2

Data Source:
HPRD (in vitro)

		TXNRD1	GLRX2
Description		thioredoxin reductase 1	glutaredoxin 2
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GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Cytoplasm Mitochondrion Cytosol Extracellular Exosome	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Dendrite Neuronal Cell Body Intracellular Membrane-bounded Organelle
	Molecular Function	Thioredoxin-disulfide Reductase Activity Protein Binding Protein Disulfide Oxidoreductase Activity Flavin Adenine Dinucleotide Binding	Protein Disulfide Isomerase Activity Protein Binding Arsenate Reductase (glutaredoxin) Activity Electron Transfer Activity Protein Disulfide Oxidoreductase Activity Glutathione Disulfide Oxidoreductase Activity Metal Ion Binding 2 Iron, 2 Sulfur Cluster Binding
	Biological Process	Mesoderm Formation Selenium Compound Metabolic Process Signal Transduction Cell Population Proliferation Nucleobase-containing Small Molecule Interconversion Regulation Of Lipid Metabolic Process Cellular Response To Oxidative Stress Cell Redox Homeostasis Cellular Oxidant Detoxification	Regulation Of Transcription, DNA-templated Glutathione Metabolic Process Apoptotic Process Aging Response To Temperature Stimulus Regulation Of Signal Transduction Response To Organic Substance Protein Phosphopantetheinylation Electron Transport Chain Cell Differentiation DNA Protection Response To Hydrogen Peroxide Cell Redox Homeostasis Response To Redox State Cellular Response To Superoxide
Pathways		PPARA activates gene expression Metabolism of ingested H2SeO4 and H2SeO3 into H2Se Detoxification of Reactive Oxygen Species Interconversion of nucleotide di- and triphosphates Metabolism of ingested MeSeO2H into MeSeH Uptake and function of diphtheria toxin TP53 Regulates Metabolic Genes
Drugs		Arsenic trioxide NADPH Flavin adenine dinucleotide Spermidine Fotemustine Motexafin gadolinium PX-12	Glutathione
Diseases
GWAS		Blood protein levels ( 30072576) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Logical memory (delayed recall) in normal cognition ( 29274321) Toenail selenium levels ( 25343990)	Blood protein levels ( 29875488)
Interacting Genes		11 interacting genes: DMRTC2 ESR1 ESR2 GLRX2 LINC01554 POU2F1 POU2F2 PPP1R16A THRA TXNDC17 TXNIP	4 interacting genes: DCXR ELF5 FBXO7 TXNRD1
Entrez ID		7296	51022
HPRD ID		03068	12112
Ensembl ID		ENSG00000198431	ENSG00000023572
Uniprot IDs		B7Z2S5 Q16881	Q9NS18
PDB IDs		1W1C 2CFY 2J3N 2ZZ0 2ZZB 2ZZC 3QFA 3QFB	2CQ9 2FLS 2HT9
Enriched GO Terms of Interacting Partners?
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