TXNDC17 and AVP

Data Source:
HPRD (in vitro)

		TXNDC17	AVP
Description		thioredoxin domain containing 17	arginine vasopressin
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Extracellular Region Extracellular Space Cytosol Secretory Granule Dendrite Clathrin-coated Vesicle Membrane
	Molecular Function	Peroxidase Activity Protein Binding Protein-disulfide Reductase Activity	Protein Kinase Activity Signaling Receptor Binding Neuropeptide Hormone Activity Neurohypophyseal Hormone Activity Protein Binding V1A Vasopressin Receptor Binding V1B Vasopressin Receptor Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process	Tumor Necrosis Factor-mediated Signaling Pathway Cellular Oxidant Detoxification	Maternal Aggressive Behavior Positive Regulation Of Systemic Arterial Blood Pressure Renal Water Homeostasis Generation Of Precursor Metabolites And Energy Protein Phosphorylation Water Transport Apoptotic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Negative Regulation Of Female Receptivity Grooming Behavior Locomotory Behavior Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Glutamate Secretion Positive Regulation Of Cell Growth Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Cellular PH Reduction Positive Regulation Of Peptidyl-serine Phosphorylation Response To Testosterone Response To Nicotine Social Behavior Regulation Of Renal Sodium Excretion Vasoconstriction Hyperosmotic Salinity Response Maternal Behavior Negative Regulation Of Apoptotic Process Penile Erection Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Ethanol Positive Regulation Of Vasoconstriction Negative Regulation Of Transmission Of Nerve Impulse Membrane Organization ERK1 And ERK2 Cascade Protein Kinase C Signaling Negative Regulation Of Release Of Cytochrome C From Mitochondria
Pathways			BMAL1:CLOCK,NPAS2 activates circadian gene expression Vasopressin-like receptors G alpha (q) signalling events G alpha (s) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) Transport of organic anions Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) ADORA2B mediated anti-inflammatory cytokines production
Drugs
Diseases			Neurohypophyseal diabetes insipidus (NPDI); Central Diabetes Insipidus
GWAS		LDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883)
Interacting Genes		9 interacting genes: AVP DYNLL1 EXOSC8 INCA1 INS OXT RUFY1 TINF2 TXNRD1	9 interacting genes: AVPR1A AVPR1B AVPR2 CRYAB DLX2 KMT2A OXTR PRKAB2 TXNDC17
Entrez ID		84817	551
HPRD ID		11656	01891
Ensembl ID		ENSG00000129235	ENSG00000101200
Uniprot IDs		A0A140VJY7 Q9BRA2	P01185 X5DQP6
PDB IDs		1WOU
Enriched GO Terms of Interacting Partners?
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