TXNRD1 and DMRTC2

Data Source:
BioGRID (two hybrid)

		TXNRD1	DMRTC2
Description		thioredoxin reductase 1	DMRT like family C2
Image			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Cytoplasm Mitochondrion Cytosol Extracellular Exosome	Chromatin Cellular_component Nucleus
	Molecular Function	Thioredoxin-disulfide Reductase Activity Protein Binding Protein Disulfide Oxidoreductase Activity Flavin Adenine Dinucleotide Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Mesoderm Formation Selenium Compound Metabolic Process Signal Transduction Cell Population Proliferation Nucleobase-containing Small Molecule Interconversion Regulation Of Lipid Metabolic Process Cellular Response To Oxidative Stress Cell Redox Homeostasis Cellular Oxidant Detoxification	Regulation Of Transcription By RNA Polymerase II Germ Cell Development Sex Differentiation Biological_process
Pathways		PPARA activates gene expression Metabolism of ingested H2SeO4 and H2SeO3 into H2Se Detoxification of Reactive Oxygen Species Interconversion of nucleotide di- and triphosphates Metabolism of ingested MeSeO2H into MeSeH Uptake and function of diphtheria toxin TP53 Regulates Metabolic Genes
Drugs		Arsenic trioxide NADPH Flavin adenine dinucleotide Spermidine Fotemustine Motexafin gadolinium PX-12
Diseases
GWAS		Blood protein levels ( 30072576) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Logical memory (delayed recall) in normal cognition ( 29274321) Toenail selenium levels ( 25343990)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		11 interacting genes: DMRTC2 ESR1 ESR2 GLRX2 LINC01554 POU2F1 POU2F2 PPP1R16A THRA TXNDC17 TXNIP	2 interacting genes: IRF9 TXNRD1
Entrez ID		7296	63946
HPRD ID		03068	16829
Ensembl ID		ENSG00000198431	ENSG00000142025
Uniprot IDs		B7Z2S5 Q16881	B4DX56 Q8IXT2
PDB IDs		1W1C 2CFY 2J3N 2ZZ0 2ZZB 2ZZC 3QFA 3QFB
Enriched GO Terms of Interacting Partners?
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